2012 Fiscal Year Final Research Report
Sonodynamic cancer therapy with tumor targeting TiO_2 nanoparticles.
| Project/Area Number |
22300177
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Kanazawa University |
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Principal Investigator |
SHIMIZU Nobuaki 金沢大学, 環日本海域環境研究センター, 教授 (50019634)
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| Co-Investigator(Kenkyū-buntansha) |
NINOMIYA Kazuaki 金沢大学, 環日本海域環境研究センター, 助教 (10379125)
KURODA Syunichi 名古屋大学, 大学院・生命農学研究科, 教授 (60263406)
MATSUMOTO Kunio 金沢大学, がん進展制御研究所, 教授 (90201780)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 二酸化チタン / 超音波触媒 / OHラジカル / ナノ粒子 / がん治療 / 機能性粒子 / 標的化 / DNAアプタマー |
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| Research Abstract |
A new sonodynamic therapy for cancer cells was proposed in this study. The delivery of titanium dioxide (TiO2) nanoparticles (NPs) modified with avidinspecifically recognizing cancer cells and subsequent generation of OH radicals from TiO2 NPs activated by external ultrasound irradiation were studied. The uptake of TiO2 NPs modified with avidin by MCF7 cells was clarified and apoptosis was observed at 6 h after the TiO2/US treatment. Although no apparent cell-injury was observed until 24 h after the treatment, the viable cell concentration had deteriorated to 46% of the control at 96 h.
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[Journal Article] Cell-SELEX based selection and characterization of DNA aptamer recognizing human hepato- carcinoma2013
Author(s)
Ninomiya, K., Kaneda, K., Kawashima, S., Miyachi, Y., Ogino, C., Shimizu, N.
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Journal Title
Bioorg. Med. Chem. Lett
Volume: 23(6)
Pages: 1797-1802
Peer Reviewed
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[Journal Article] Targeted sonodynamic therapy using protein-modified TiO_2 nanoparticles2012
Author(s)
Ninomiya, K., Ogino, C., Oshima, S., Sonoke, S., Kuroda, S., Shimizu, N.
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Journal Title
Ultrason. Sonochem.
Volume: 19(3)
Pages: 607-614
Peer Reviewed
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[Journal Article] Construction of protein-modified TiO_2 nanoparticles for use with ultrasound irradiation in a novel cell-injuring method2010
Author(s)
Ogino, C., Shibata, N., Sasai, R., Takaki, K., Miyachi, Y., Kuroda, S.,Ninomiya, K., Shimizu, N.
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Journal Title
Bioorg. Med. Chem. Lett.
Volume: 20(17)
Pages: 5320-5325
Peer Reviewed
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[Journal Article] Ultrasonic inactivation of Microcystis aeruginosa in the presence of TiO_2 particles
Author(s)
Ninomiya, K.,Ogino, C., Kawabata, S., Maki, T., Hasegawa, H.,Shimizu, N.
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Journal Title
J. Biosci. Bioeng
Volume: (in press)
Peer Reviewed
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[Presentation] Targeted sonodynamic therapy using proteinmodified TiO_2 nanoparticles, Proc.2011
Author(s)
Ninomiya, K., Oshima, S., Sonoke, S., Ogino, C., Kuroda, S., Shimizu, N.
Organizer
the 20th Annual Meeting of the Japan Society of Sonochem. & The Int. Workshop on Adv.Sonochem
Place of Presentation
Nagoya
Year and Date
20111100
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