2012 Fiscal Year Final Research Report
Development of electric stimulation to inhibit post-operative hyper catabolism of skeletal muscles
| Project/Area Number |
22300186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
YAMADA Sumio 名古屋大学, 医学系研究科(保健), 教授 (80359752)
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| Co-Investigator(Kenkyū-buntansha) |
KAWABE Tsutomu 名古屋大学, 医学部, 教授 (20378219)
USUI Akihiko 名古屋大学, 医学部, 教授 (30283443)
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| Co-Investigator(Renkei-kenkyūsha) |
KONDO Takaaki 名古屋大学, 医学部, 教授 (00195900)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 心大血管術後患者 / 異化亢進 / 筋タンパク分解 / 電気刺激介入 |
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| Research Abstract |
[Study 1] We investigated skeletal muscle proteolysis and postoperative muscle weakness immediately after cardiovascular surgery(CVS) based on 24 hour urinary 3-methylhistidine/Creatinine(24h-u3MH/Cre). [Methods]Thirty seven patients underwent CVS were enrolled. Iterleukin-6(IL-6) production, cortisol, growth hormone(GH), IGF-1, BCAA, AAA, respiratory muscle power, grasp strength, knee extension strength and 24h-u3MH were measured. [Results]IL-6 and cortisol increased immediately after the CVS and IGF-1/GH and BCAA/AAA decreased, showing postoperative hypercatabolism. 24h-u3MH/Cre successively increased and peak out at 4th postoperative day and cumulative value during 5 days significantly correlated with IL-6 production and the magnitude of decrease in knee extension muscle strength. [Conclusions] Hyper-catabolism due to CVS correlates with postsurgical muscle proteolysis and muscle weakness.[Study 2] We investigated the feasibility of electrical stimulation (ES) intervention and the preventive effect of ES on postoperative muscle proteolysis in patients immediately after cardiovascular surgery by nonrandomized controlled trial.-Feasibility study; Sixty eight patients were consecutively recruited to the study from November 2011. Patients received ES from postoperative day (POD) 1 for 2 weeks and we found no clinical adverse event and they cleared criteria for success of feasibility.-Nonrandomized controlled trial; We compared 32 patients who received ES group with 32 patients who didn’t by group matching based on obesity and IL-6 immediate after surgery. The values of 3MH/Cre on POD4 and POD5 adjusted by that of POD1 were significantly low in ES group. We also found little reduction (
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[Presentation] Feasibility Of New Device For Electrical Muscle Stimulation Immediately After Cardiovascular Surgery2013
Author(s)
Iwatsu K, Iida Y, Sampei H, Kono Y, Hagiwara Y, Ishida S, Iritani N, Kobayashi K, Kainuma M, Kawabe T, Usui A, Yamada S
Organizer
American Thoracic Society International Conference 2013
Place of Presentation
Pennsylvania Convention Center, USA
Year and Date
2013-05-19
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[Presentation] 左室人工補助循環装置装着後患者における手術前からの分岐鎖アミノ酸補給と手術後電気刺激療法による下肢筋力ならびに筋量の改善効果2013
Author(s)
岩津弘太郎, 小林聖典, 河野裕治, 三瓶秀幸, 萩原悠太, 石田慎平, 入谷直樹, 貝沼関志, 六鹿雅登, 碓氷章彦, 山田純生
Organizer
第77回日本循環器学会学術集会
Place of Presentation
パシフィコ横浜
Year and Date
2013-03-16
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[Presentation] 心大血管外科手術後早期における電気刺激療法の実施可能性に関する検討2012
Author(s)
岩津弘太郎, 山田純生, 三瓶秀幸, 河野裕治, 萩原悠太, 入谷直樹, 石田慎平, 小林聖典, 貝沼関志, 川部勤, 碓氷章彦
Organizer
第18回日本心臓リハビリテーション学会学術集会
Place of Presentation
大宮ソニックシティ
Year and Date
2012-07-14
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