CEREBRAL BLOOD FLOW REGULATION DURING EXERCISE IN TWO ROOTS OF BRAIN ARTERY

2012 Fiscal Year Final Research Report

• Project/Area Number: 22300205
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical education
• Research Institution: Japan Women's College of Physical Education
• Principal Investigator: SADAMOTO Tomoko 日本女子体育大学, 体育学部, 教授 (30201528)
• Co-Investigator(Kenkyū-buntansha): OGO Shigehiko 東洋大学, 理工学部, 教授 (80553841)
• Co-Investigator(Renkei-kenkyūsha): SATO Kouhei 日本女子体育大学, 体育学部, 准教授 (00409278) ; OOUE Anna 日本女子体育大学, 附属基礎体力研究所, 助教 (00550104)
• Project Period (FY): 2010 – 2012
• Keywords: 前頭部脳循環 / 後頭部脳循環 / 内頸動脈 / 椎骨動脈 / 中大脳動脈 / 超音波法 / 動脈 CO_2 / 自動調節

Research Abstract

Blood supply to the brain originates from two roots, the internal carotid arteries (ICA) and the vertebral arteries (VA). ICA provides blood to cerebral cortex forming the anterior cerebral circulation, while VA supplies blood to occipital cortex, cerebellum, and brainstem forming the posterior cerebral circulation. Although previous studies assumed that the cerebral blood flow in two roots were similar during exercise, the present study demonstrated that there are different responses between two roots indicating regional differences in the brain circulation. Further, difference in arterial CO_2 reactivity found to be a mediator for the regional difference in the brain circulation.

Research Products

• [Journal Article] Differential blood flow responses to CO_2 in human internal and external carotid and vertebral arteries (2012)
  • Author(s): Sato, K., Sadamoto,T. ,Hirasawa, A., Oue, A., Subudhi, A.W., Miyazawa, T. and Ogoh, S.
  • Journal Title: J Physiol Volume: 590 Pages: 3277-3290
  • DOI: doi:10.1113/jphysiol
  • Peer Reviewed
• [Journal Article] The distribution of blood flow in the carotid and vertebral arteries during dynamicexercise in humans. (2011)
  • Author(s): Sato, K., Ogoh, S., Hirasawa, A., Oue, A., Sadamoto, T.
  • Journal Title: J Physiol Volume: 589 Pages: 2847-2856
  • DOI: doi:10.1113/jphysiol.2010.204461
  • Peer Reviewed
• [Journal Article] Different blood flow responses to dynamic exercise between internal carotid artery and vertebral artery in women. (2010)
  • Author(s): Sato, K. and Sadamoto, T.
  • Journal Title: J Appl Physiol Volume: 109 Pages: 864-869
  • DOI: doi:10.1152/japplphysiol.01359.2009
  • Peer Reviewed
• [Journal Article] Cerebrovascular response during heavyupper body exercise: effect of mode of ventilation on blood flow velocity in the middle cerebral artery. (2010)
  • Author(s): Sato, K., Hirasawa, A., Tsunoda, N., Taniguchi, Y. and Sadamoto, T.
  • Journal Title: Adv Exp Med Biol Volume: 66 Pages: 347-352
  • DOI: doi:10.1007/978-1-4419-1241-1_50
  • Peer Reviewed
• [Journal Article] Dynamic cerebral autoregulation during and after handgrip exercise in humans. (2010)
  • Author(s): Ogoh, S., Sato, K., Akimoto, T.,Oue, A., Hirasawa, A. and Sadamoto, T.
  • Journal Title: J Appl Physiol Volume: 108 Pages: 1701-1705
  • DOI: doi:10.1152/japplphysiol.01031
  • Peer Reviewed
• [Presentation] 動的運動時における頭部静脈血流応答特性 (2012)
  • Author(s): 大上安奈,平澤愛,佐藤耕平,米谷茉里奈,定本朋子
  • Organizer: 第20回日本運動生理学会大会
  • Place of Presentation: 茨城
  • Year and Date: 2012-07-29
• [Presentation] Cerebral blood flow regulation in internal carotid and vertebral arteries during orthostatic stress. (2012)
  • Author(s): Ogoh, S., Sato ,K., Fisher,J.P., Seifert, T., Overgaard, M. and Secher, N.H.
  • Organizer: The 17th Annual Congress of the European College of Sport Science
  • Place of Presentation: Bruges, Belgium
  • Year and Date: 2012-07-06
• [Presentation] 4週間の持久性トレーニングが運動時の脳血流動態へ及ぼす影響 (2011)
  • Author(s): 米谷茉里奈,佐藤耕平,大上安奈,平澤愛,定本朋子
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 山口
  • Year and Date: 2011-09-17
• [Presentation] アドレナリン作動薬が動静脈脳血流量に及ぼす影響 (2011)
  • Author(s): 小河繁彦,佐藤平,Fisher J.P.,Secher,N.H.
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 山口
  • Year and Date: 2011-09-16
• [Presentation] 運動時脳血流のCO_2reactivity指標に及ぼす持久性トレーニングの影響 (2011)
  • Author(s): 米谷茉里奈,佐藤耕平,大上安奈,平澤愛,定本朋子
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 岐阜
  • Year and Date: 2011-09-15
• [Presentation] 起立ストレスによる中枢性呼吸反射変化のメカニズム (2011)
  • Author(s): 小河繁彦,岡崎和伸,中原秀英,宮本忠吉
  • Organizer: 第25回呼吸研究会
  • Place of Presentation: 山口
  • Year and Date: 2011-09-15
• [Presentation] Elevation blood flow in common carotid artery with aerobic fitness in elderly women (2011)
  • Author(s): Hirasawa, A., Sato, K., Ooue, A., Nakamura, I., Sadamoto, T.
  • Organizer: The 16th Annual Congress of the European College of Sport Science
  • Place of Presentation: Liverpool UK.
  • Year and Date: 2011-07-08
• [Presentation] Heterogeneous cerebrovascular responses to dynamicexercise in anatomically distinct cerebral arteries. (2011)
  • Author(s): Sato, K., Hirasawa, A., Oue, A., Ogoh, S., Sadamoto, T.
  • Organizer: The 57th American College of Sports Medicine
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-06-03
• [Presentation] 1週間の高強度レジスタンストレーニングが静的運動時の中大脳動脈に及ぼす影響 (2010)
  • Author(s): 米谷茉里奈,大上安奈,平澤愛,佐藤耕平,定本朋子
  • Organizer: 第65回日本体力医学会大会
  • Place of Presentation: 千葉
  • Year and Date: 2010-09-17
• [Presentation] Central command and vertebral blood flow during static arm exercise in humans (2010)
  • Author(s): Sato, K. and Sadamoto, T.
  • Organizer: The 57th American College of Sports Medicine
  • Place of Presentation: Baltimore,USA
  • Year and Date: 2010-06-10