Role of perlecan in muscle hypertrophy induced by mechanical-stress

2012 Fiscal Year Final Research Report

• Project/Area Number: 22300223
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Juntendo University
• Principal Investigator: HIRASAWA Eri 順天堂大学, 大学院・医学研究科, 准教授 (50245718)
• Co-Investigator(Kenkyū-buntansha): NAITO Hisashi 順天堂大学, スポーツ健康科学研究科, 教授 (70188861)
• Project Period (FY): 2010 – 2012
• Keywords: メカニカルストレス / サルコペニア / ミオスタチ / パールカン

Research Abstract

The aim of this study is to identify the role of perlecan, a multifunctional glycoprotein, in skeletal muscle hypertrophy induced by mechanical stress such as exercise training. We found that in perlecan deficient mice, skeletal muscle hypertrophy was promoted with increased growth factor and myostatin signaling under the mechanical stress. Our findings reveal the important regulatory role of perlecan in muscle hypertrophy induced by mechanical stress.

Research Products

• [Journal Article] Mercier F Fractone-heparan sulfates mediate FGF-2 stimulation of cell proliferation in the adult subventricular zone (2013)
  • Author(s): Douet V, Arikawa-Hirasawa E
  • Journal Title: Cell Prolif Volume: 46(2) Pages: 137-145
  • Peer Reviewed
• [Journal Article] Heat stress activates the Akt/mTOR signaling pathway in rat skeletal muscle (2013)
  • Author(s): Yoshihara T, Naito H, Kakigi R, Ichinoseki-Sekine N, Ogura Y, Sugiura T, Katamoto S
  • Journal Title: Acta Physiol Volume: 207 Pages: 416-26
  • Peer Reviewed
• [Journal Article] Laminin a1 is essential for mouse cerebellar development (2012)
  • Author(s): Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu Z, Kamikubo Y, Sakurai,T, Kohsaka S, Chiba H, Hattori H, Yamada Y, and Arikawa-Hirasawa E
  • Journal Title: Matrix Biol Volume: 311 Pages: 17-28
  • Peer Reviewed
• [Journal Article] Heparan sulfate niche for cell proliferation in the adult brain (2012)
  • Author(s): Mercier F, Arikawa-Hirasawa E
  • Journal Title: Neuroscience Letters Volume: Apr 15;315(1-2) Pages: 15-9
  • Peer Reviewed
• [Journal Article] A novel mutation in SCN4A causes severe myotonia and school-age-onset paralytic episodes. (2012)
  • Author(s): Yoshinaga H, Sakoda,S Good JM, Takahashi MP, Kubota T, Arikawa-Hirasawa E, Nakata T, Ohno K, Kitamura T, Kobayashi K, and Ohtsuka Y
  • Journal Title: Journal of the Neurological Sciences Volume: Apr 15;315(1-2) Pages: 15-9
  • Peer Reviewed
• [Journal Article] Perlecan-Deficient Mutation Impairs Corneal Epithelial Structure (2012)
  • Author(s): Inomata T , Ebihara N, Funaki, T Matsuda A, Watanabe Y, Ning L, Xu Z, Murakami A, Arikawa-Hirasawa E
  • Journal Title: Invest Ophthalmol Vis Sci Volume: Mar 9;53(3) Pages: 1277-84
  • Peer Reviewed
• [Journal Article] Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation (2012)
  • Author(s): Ishijima M, Suzuki N, Hozumi K, Matsunobu T, Kosaki K, Kaneko H, Hassell JR, Arikawa-Hirasawa E, Yamada Y
  • Journal Title: Matrix Biol Volume: (4) Pages: 234-45
  • Peer Reviewed
• [Journal Article] Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS (2012)
  • Author(s): Suzuki N, Fukushi M, Kosaki K, Doyle AD, de Vega S, Yoshizaki K, Akazawa C, Arikawa-Hirasawa E, Yamada Y
  • Journal Title: J Neurosci Volume: Aug 22;32(34) Pages: 11586-99
  • Peer Reviewed
• [Journal Article] Fractone-heparan sulfates mediate BMP-7 inhibition of cell proliferation in the adult subventricular zone (2012)
  • Author(s): Douet V, Arikawa-Hirasawa E,Mercier F
  • Journal Title: Neurosci Lett Neurosci Lett Volume: 24;528(2) Pages: 120-5
  • Peer Reviewed
• [Journal Article] Fiber-type specific expression of -actinin isoforms in rat skeletal muscle (2012)
  • Author(s): Ichinoseki-Sekine N, Yoshihara T, Kakigi R, Ogura Y, Sugiura T, Naito H
  • Journal Title: Biochem Biophys Res Commun Volume: 419 Pages: 401-404
  • Peer Reviewed
• [Journal Article] Heat stress-induced changes in skeletal muscle: heat shock proteins and cellular signaling transduction (2012)
  • Author(s): Naito H, Yoshihara T, Kakigi R, Ichinoseki-Sekine N, Tsuzuki T
  • Journal Title: J Phys Fitness Sports Med Volume: 1 Pages: 125-131
  • Peer Reviewed
• [Journal Article] Satellite cell pool enhancement in rat plantaris muscle by endurance training depends on intensity rather than duration (2012)
  • Author(s): Kurosaka M, Naito H, Ogura Y, Machida S, Katamoto S
  • Journal Title: Acta Physiol Volume: 205 Pages: 159-66
  • Peer Reviewed
• [Journal Article] Dynamic mathematical modeling of cell-fractone interactions (2011)
  • Author(s): Chyba M, Mercier F, RaderJ, Douet V Arikawa-Hirasawa E, Kwon YC, Kodama R
  • Journal Title: Journal of Math-for-Industry Volume: Vol. 3 Pages: 79-88
  • Peer Reviewed
• [Journal Article] Single bout of running exercise changes LC3-II expression in rat cardiac muscle (2011)
  • Author(s): Ogura Y, Iemitsu M, Naito H, Kakigi R, Kakehashi C, Maeda S, Akema T
  • Journal Title: Biochem Biophys Res Commun Volume: 414 Pages: 756-760
  • Peer Reviewed
• [Journal Article] Katamoto. Heat stress enhances mTOR signaling after resistance exercise in human skeletal muscle (2011)
  • Author(s): Kakigi R, Naito H, Ogura Y, Kobayashi H, Saga N, Ichinoseki-Sekine N, Yoshihara T
  • Journal Title: J Physiol Sci Volume: 61 Pages: 131-140
  • Peer Reviewed
• [Journal Article] Association of the HSPG2 gene withneuroleptic-induced tardive dyskinesia (2010)
  • Author(s): Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ishikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T
  • Journal Title: Neuropsychopharmacolog Volume: 35(5) Pages: 1155-64
  • Peer Reviewed
• [Journal Article] Distinct Mechanosensitive Ca2+ Influx Mechanisms in Human Primary Synovial Fibroblasts (2010)
  • Author(s): Sakamoto Y, Ishijima M, Kaneko H, Kurebayashi N, Ichikawa N, Futami I, Kurosawa H, Arikawa-Hirasawa E
  • Journal Title: J Orthop Res Volume: 28 Pages: 859-864
  • Peer Reviewed
• [Journal Article] Pigment epithelium-derived factor up-regulation induced by memantine,an N-methyl-d-aspartate receptor antagonist, is involved in increased proliferation of hippocampal progenitor cells (2010)
  • Author(s): Namba T, Yabe T, Gonda Y, Ichikawa N, Sanagi T, Arikawa-Hirasawa E,Mochizuki H, Kohsaka S, Uchino S
  • Journal Title: Neuroscience Volume: 167(2) Pages: 372-83
  • Peer Reviewed
• [Journal Article] Perlecan deficiency causes muscle hypertrophy, a decrease in myostatin expression, and changes in muscle fiber composition (2010)
  • Author(s): Xu Z, Ichikawa N, Kosaki K, Yamada Y, Sasaki T, Sakai LY Kurosawa H, Hattori N, Arikawa-Hirasawa E
  • Journal Title: Matrix Biol Volume: 29(6) Pages: 461-70
  • Peer Reviewed
• [Journal Article] Laminin-121-Recombinant expression and interactions with integrins (2010)
  • Author(s): Sasaki T, Takagi J, Giudici C, Yamada Y, Arikawa-Hirasawa E,Deutzmann R, Timpl R, Sonnenberg A, Bachinger HP, Tonge D.
  • Journal Title: MatrixBiol Volume: 29(6) Pages: 484-93
  • Peer Reviewed
• [Journal Article] Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis (2010)
  • Author(s): Ning L, Ishijima M, Kaneko H, Kurihara H, Arikawa-Hirasawa E,Kubota M, Liu L, Xu Z, Futami I, Yusup A, Miyahara K, Xu S, Kaneko K, Kurosawa H
  • Journal Title: Int. Orthop Volume: 35(6) Pages: 931-8
  • Peer Reviewed
• [Journal Article] Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats (2010)
  • Author(s): Koltai E, Szabo Z, Atalay M, Boldogh I, Naito H, Goto S, Nyakas C, Radak Z
  • Journal Title: Mech Ageing Dev Volume: 131 Pages: 21-29
  • Peer Reviewed
• [Journal Article] Isolation and Characterization of MultipotentialMesenchymal Cells from the Mouse Synovium
  • Author(s): Futami I, Ishijima M, Kaneko H, Tsuji K, Ichikawa-Tomikawa N, Sadatsuki R, Muneta T, Arikawa-Hirasawa E, Sekiya I, Kaneko K
  • Journal Title: PLoS ONE Volume: 7(9) Pages: e45517 1-12
  • Peer Reviewed