Identification of molecular target for cancer therapy involved in the spindle assembly

2012 Fiscal Year Final Research Report

• Project/Area Number: 22300321
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Carcinogenesis
• Research Institution: Japanese Foundation For Cancer Research
• Principal Investigator: YAO Ryouji 公益財団法人がん研究会, がん研究所細胞生物部, 主任研究員 (80291095)
• Co-Investigator(Kenkyū-buntansha): NAGASAKI Koichi がん研究会, ゲノムセンター, 研究員 (90250208)
• Project Period (FY): 2010 – 2012
• Keywords: 遺伝子改変動物

Research Abstract

Although the mitotic spindle is an established target for the cancer chemotherapy, current anti-cancer drugs led to the serious side-effects caused by the disturbance of the microtubule functions in post-mitotic cells. In this study, by the extensive expression study as well as the functional analysis, we identified the genes that were highly expressed in human cancers and the tumor growth were suppressed when their functions were inhibited. Our analysis demonstrated that these genes were potential targets for the cancer chemotherapy

Research Products

• [Journal Article] Disruption of Tacc3 function leads to in vivo tumor regression (2012)
  • Author(s): Yao, R., Natsume, Y., Saiki, Y., Shioya, H., Takeuchi, K., Yamori, T., Toki, H., Aoki, I., Saga, T. & Noda, T
  • Journal Title: Oncogene Volume: 31 Pages: 135-48
• [Journal Article] Appearance of an oocyte activation-related substance during spermatogenesis in mice and humans (2011)
  • Author(s): Ito, C., Yamatoya, K., Yoshida, K., Kyono, K., Yao, R., Noda, T. & Toshimori, K
  • Journal Title: Hum Reprod Volume: 25 Pages: 2734-44
• [Presentation] がん細胞の紡錘体形成においてTACC3とTOGpは時間的・空間的に異なる役割を担う (2012)
  • Author(s): 八尾良司、夏目康子、矢守隆夫、野田哲生
  • Organizer: 第35回分子生物学会
  • Place of Presentation: (福岡)
  • Year and Date: 20121200
• [Presentation] TACC3とTOGpは、紡錘体形成において時間的・空間的に異なる機構を持つ (2012)
  • Author(s): 八尾良司、矢守隆夫、野田哲生
  • Organizer: 第71回日本癌学会
  • Place of Presentation: (札幌)
  • Year and Date: 20120900
• [Presentation] Disruption of TACC3 leads to in vivo tumor regression by targeting spindle assembly (2012)
  • Author(s): Ryoji Yao and Tetsuo Noda
  • Organizer: The 16th Japanease Foundation for Cancer Research International Symposium on Cancer Chemotherapy
  • Place of Presentation: (Tokyo)
  • Year and Date: 20120625-26
• [Presentation] がん細胞紡錘体形成におけるTACC3の機能とがん分子治療標的への応用 (2012)
  • Author(s): 八尾良司、矢守隆夫
  • Organizer: 日本がん分子標的治療学会
  • Place of Presentation: (北九州市)
  • Year and Date: 20120000
• [Presentation] 細胞分裂の基礎研究と臨床応用への展開 第三次対がん10カ年総合戦略・文部科学省がん支援活動 (2012)
  • Author(s): 八尾良司
  • Organizer: 合同公開シンポジウム
  • Place of Presentation: (東京)
  • Year and Date: 20120000
• [Presentation] TACC3による中心体紡錘体とキネトコア紡錘体の選択的制御 (2011)
  • Author(s): 八尾良司、夏目康子、矢守隆夫、野田哲生
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: (横浜)
  • Year and Date: 20110000
• [Presentation] Disruption of Tacc3 function leads to tumor regression in vivo (2011)
  • Author(s): Ryoji Yao
  • Organizer: 13th Japanease-German Cancer Workshop
  • Place of Presentation: (Hiroshima)
  • Year and Date: 20110000
• [Presentation] がんモデルマウスを用いたTacc3を標的としたがん治療法の開発 (2011)
  • Author(s): 八尾良司、塩谷尚志、斎木由利子、野田哲生
  • Organizer: 第70回日本癌学会
  • Place of Presentation: (名古屋)
  • Year and Date: 20110000
• [Presentation] がん分子治療標的としてのTACC3 (2010)
  • Author(s): 八尾良司、野田哲生
  • Organizer: 第69回日本癌学会
  • Place of Presentation: (大阪)
  • Year and Date: 20100000