2012 Fiscal Year Final Research Report
Correlation between vasohibin family and tumor angiogenesis/cancer stem cell
| Project/Area Number |
22300323
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Tohoku University |
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Principal Investigator |
YASUFUMI Sato 東北大学, 加齢医学研究所, 教授 (50178779)
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| Co-Investigator(Kenkyū-buntansha) |
HIROKI Miyashita 東北大学, 加齢医学研究所, 助教 (80302222)
YASUHIRO Suzuki 東北大学, 加齢医学研究所, 助教 (60332277)
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| Project Period (FY) |
2010 – 2012
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| Keywords | VASH1 / VASH2 / 血管内皮細胞 / がん細胞 / 血管新生 / がん転移 |
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| Research Abstract |
Vasohibin family is composed with 2 proteins, vasohibin-1 (VASH1) and vasohibin-2 (VASH2). VASH1 is an angiogenesis inhibitor induced in endothelial cells (ECs) by pro-angiogenic stimuli. Our recent analysis revealed that VASH1 is expressed in ECs of tumor vessels, and this endogenous VASH1 inhibits tumor growth by its anti-angiogenic activity. In the present study, we showed that endogenous VASH1 is also responsible for the inhibition of cancer metastasis. In contrast to VASH1, our present study revealed that VASH2 is expressed in cancer cells. This cancer cell-produced VASH2 augments cancer growth by stimulating angiogenesis. From these results, we proposed that the balance between VASH1 and VASH2 is critical for cancer progression.
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[Journal Article] Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma2013
Author(s)
Xue X, Gao W, Sun B, Xu Y, Han B, Wang F, Zhang Y, Sun J, Wei J, Lu Z, Zhu Y, Sato Y, Sekido Y, Miao Y, Kondo Y
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Journal Title
Oncogene
Volume: 32
Pages: 1724-1734
DOI
Peer Reviewed
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[Journal Article] The prognostic significance of vasohibin-1 expression in patients with upper urinary tracturothelial carcinoma2012
Author(s)
Miyazaki Y, Kosaka T, Mikami S, Kikuchi E, Tanaka N, Maeda T, Ishida M, Miyajima A, Nakagawa K, Okada Y, Sato Y, Oya M
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Journal Title
Clin Cancer Res
Volume: 18
Pages: 4145-4153
DOI
Peer Reviewed
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[Journal Article] Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas2011
Author(s)
Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H, Yaegashi N, Sato Y
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Journal Title
Cancer Sci
Volume: 102
Pages: 446-51
DOI
Peer Reviewed
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