Analysis of molecular oncogenesis for lung cancer with fusion kinases

2012 Fiscal Year Final Research Report

• Project/Area Number: 22300326
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor biology
• Research Institution: The University of Tokyo
• Principal Investigator: SAI Eirin 東京大学, 大学院・医学系研究科, 特任准教授 (40458295)
• Project Period (FY): 2010 – 2012
• Keywords: がん遺伝子

Research Abstract

In 2007, we discovered the EML4-ALK fusion-type oncogene in lung cancer, and aspecific inhibitor against ALK kinase is already approved and used as a therapeuticdrug. Here we examined lung cancer specimens before and after relapse against theALK inhibitor treatment, and have identified secondary mutations within EML4-ALK thataccount for drug resistance. Further, we established multiplex RT-PCR system for thediagnosis of EML4-ALK-positive lung cancer, and confirmed its reliability in a largescale Japanese cohort.

Research Products

• [Journal Article] (2013)
  • Author(s): Kawazu M, Ueno T, Kontani K, Ogita Y, Ando M, Fukumura K, Yamato A, Soda M, Takeuchi K, Miki Y, Yamaguchi H, Yasuda T, Naoe T,Yamashita Y, Katada T, Choi YL, Mano H,
  • Journal Title: Proc Natl Acad Sci U S A Volume: 110 Pages: 3029-3034
  • DOI: DOI:10.1073/pnas.1216141110
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Choi YL, Soda M, Ueno T, Hamada T, Haruta H, Yamato A, Fukumura K, Ando M, Kawazu M, Yamashita Y, Mano H
  • Journal Title: Carcinogenesis Volume: 33 Pages: 956-961
  • DOI: DOI:10.1093/carcin/bgs099
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Soda M, Isobe K, Inoue A, Maemondo M,Oizumi S, Fujita Y, Gemma A, Yamashita Y,Ueno T, Takeuchi K, Choi YL, Miyazawa H,Tanaka T, Hagiwara K, Mano H
  • Journal Title: Clin Cancer Res Volume: 18 Pages: 5682-5689
  • DOI: DOI:10.1158/1078-0432.CCR-11-2947
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Takeuchi K, Soda M, Togashi Y, Suzuki R,Sakata S, Hatano S, Asaka R, Hamanaka W,Ninomiya H, Uehara H, Choi YL, Satoh Y, Okumura S, Nakagawa K, Mano H, IshikawaY
  • Journal Title: Nat Med Volume: 18 Pages: 378-381
  • DOI: DOI:10.1038/nm.2658
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Ueno T, Yamashita Y, Soda M, Fukumura K, Ando M, Yamato A, Kawazu M, Choi YL,Mano H
  • Journal Title: Cancer Sci Volume: 103 Pages: 131-135
  • DOI: DOI:10.1111/j.1349-7006.2011.02105.x
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE,Hayashi T, Yanagihara K, Moriwaki Y,Miyazaki Y, Kamihira S, Yamada Y,
  • Journal Title: Haematologica Volume: 96 Pages: 712-719
  • DOI: DOI:10.3324/haematol.2010.028605
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Suzuki HI, Arase M, Matsuyama H, Choi YL,Ueno T, Mano H, Sugimoto K, Miyazono K,
  • Journal Title: Mol Cell Volume: 44 Pages: 424-436
  • DOI: DOI:10.1016/j.molcel.2011.09.012
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Choi YL, Soda M, Yamashita Y, Ueno T,Takashima J, Nakajima T, Yatabe Y, Takeuchi K, Hamada T, Haruta H, Ishikawa Y, Kimura H, Mitsudomi T, Tanio Y, Mano H
  • Journal Title: N Engl J Med Volume: 363 Pages: 1734-1739
  • DOI: DOI:10.1056/NEJMoa1007478
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Hatanaka H, Takada S, Tsukui M, Choi YL, Kurashina K, Soda M, Yamashita Y, Haruta H,Hamada T, Tamada K, Hosoya Y, Sata N,Nagai H, Yasuda Y, Sugano K, Mano H,
  • Journal Title: Cancer Sci Volume: 101 Pages: 60-64
  • DOI: DOI:10.1111/j.1349-7006.2009.01355.x
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Hatanaka H, Tsukui M, Takada S, Kurashina K,Choi YL, Soda M, Yamashita Y, Haruta H,Hamada T, Ueno T, Tamada K, Hosoya Y,Sata N, Yasuda Y, Nagai H, Sugano K, Mano H
  • Journal Title: Cancer Sci Volume: 101 Pages: 54-59
  • DOI: DOI:10.1111/j.1349-7006.2009.01348.x
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Osoegawa A, Nosaki K, Miyamoto H,Kometani T, Hirai F, Ondo K, Seto T, Sugio K,Choi YL, Soda M, Mano H, Ichinose Y
  • Journal Title: Intern Med Volume: 49 Pages: 603-606
  • DOI: DOI:10.2169/internalmedicine.49.3126
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Yamashita Y, Yuan J, Suetake I, Suzuki H,Ishikawa Y, Choi YL, Ueno T, Soda M,Hamada T, Haruta H, Takada S, Miyazaki Y,Kiyoi H, Ito E, Naoe T, Tomonaga M, Toyota M, Tajima S, Iwama A, Mano H
  • Journal Title: Oncogene, Volume: 29 Pages: 3723-3731
  • DOI: DOI:10.1038/onc.2010.117
  • Peer Reviewed
• [Presentation] ALK チロシンキナーゼ阻害剤耐性獲得機構の解明 (2011)
  • Author(s): 崔 永林
  • Organizer: 第70回日本癌学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20111003-1005