2012 Fiscal Year Final Research Report
Functional study on the regulatory role of reactive oxygen species-generating oxidase Nox1 in cancer development
| Project/Area Number |
22300328
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Tumor biology
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
KAMATA Tohru 信州大学, 医学部, 教授 (40056304)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ADACHI Yoshifumi 信州大学, 医学部, 准教授 (50201893)
FURITA Syuichi 信州大学, 医学部, 助教 (80126705)
KATOH Masayoshi 信州大学, 医学部, 助教 (70402104)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
WAKABAYASI Yuichi 新潟大学, 医歯学系, 准教授 (40303119)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | Nox4 / Ras, Wnt / 活性酸素 / EMT / HTLV -1 |
|---|
| Research Abstract |
Research effort has been made to investigate the functional role of ROS-generating Nox family enzymes in cancer development. We have found that Nox1 and Nox4 mediate cellular senescence, both Wnt-β-catenin signaling in colon cancer and recovery of inflammantion in the colon epithelium, and that Nox5 is required for adult T -cell leukemia virus-induced transformation. These results further support that Nox-derived ROS play an essential role in carcinogenesis and inflammation and underscore importance of Nox enzymes as therapeutic targets in cancer prevention.
|
Research Products
(15 results)
-
-
-
[Journal Article] Reactive oxygen generated by NADPH oxidase 1 (Nox1) contributes to cell invasion by regulating matrix metalloprotease-9 production and cell migration2010
Author(s)
Shinohara M, Adachi Y, Mitsushita J, Kuwabara M, Nagasawa A, Harada S, Furuta S, Zhang Y, Seheli K, Miyazaki H, Kamata T.
-
Journal Title
J Biol Chem.
Volume: 285
Pages: 4481-4488
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
