2012 Fiscal Year Final Research Report
Development of a tumor diagnosis system using novel immuno-PET/MRI probe
| Project/Area Number |
22300337
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HATAZAWA Jun 大阪大学, 医学系研究科, 教授 (70198745)
SEINO Satoshi 大阪大学, 大学院・工学研究科, 講師 (90432517)
MUKAI Yohe 大阪大学, 大学院・薬学研究科, 助教 (60444501)
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| Project Period (FY) |
2010 – 2012
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| Keywords | イメージング / モノクローナル抗体 / 腫瘍血管 / PET/MRI |
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| Research Abstract |
In this study, we isolated and purified a tumor vascular endothelial cell specific monoclonal antibody as tumor targeting device. This monoclonal antibody which was labeled by RI functioned as a tumor imaging probe. Furthermore, we tried development as an imaging probe for immuno-PET/MRI using this antibody. As a result, we have established the technology to produce the PEGylated gold/iron oxide magnetic nanoparticles, which has modified monoclonal antibody on the tip of PEG chain, as a novel magneticresonance imaging agent.
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[Journal Article] Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody2013
Author(s)
M. Yoshikawa, Y. Mukai, Y. Okada, Y. Tsumori, S. Tsunoda, Y. Tsutsumi, W. C. Aird, Y. Yoshioka, N. Okada, T. Doi, S. Nakagawa
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Journal Title
Blood
Volume: 121
Pages: 2804-2813
DOI
Peer Reviewed
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[Journal Article] Simple PEG conjugation of SPIO via an Au-S bond improves its tumor targeting potency as a novel MR tumor imaging agent2010
Author(s)
H. Kojima, Y. Mukai, M. Yoshikawa, K. Kamei, T. Yoshikawa, M. Morita, T. Inubushi, TA. Yamamoto, Y. Yoshioka, N. Okada, S. Seino, S. Nakagawa
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Journal Title
Bioconjug Chem
Volume: 21
Pages: 1026-1031
DOI
Peer Reviewed
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