2012 Fiscal Year Final Research Report
Effects of nuclear receptor-activating compounds produced By microalgae on aquatic animal
| Project/Area Number |
22310020
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental impact assessment/Environmental policy
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAISHI Fujio 国立環境研究所, 環境リスク研究センター, フェロー (30113476)
SANO Toharu 国立環境研究所, 環境リスク研究センター, 主任研究員 (10178808)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 7-hydroxy retinoic acid / RAR agonistic activity / Cyanobacteria / Teratogen |
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| Research Abstract |
A novel analogue of retinoic acid, 7-hydroxy retinoic acid, was found in waterbloom-forming cyanobacteria. The analogue had an agonistic activity against retinoic acid receptor (RAR) as a kind of nuclear receptors. The novel analogue was isolated from mass-cultured Spirulina sp.(TU-3).The analogue was found in all-tested strains of cyanobacteria. The analogue exist a mixture of four isomers by cis-trans isomerization including keto-enol tautomerism. The agonistic activity of the analogue against RAR was a half of all-trans retinoic acid (ATRA). The analogue was far-stable under UV-A compared with ATRA. The stability of 7-hydroxy retinoic acid under UV-A suggest that amphibians and fishes living in waterblooms occurring waters may be exposure, and give teratogenic effects.
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Research Products
(3 results)
