2012 Fiscal Year Final Research Report
Development of a biological dosimeter to detect the DNA damage induced by low dose radiation and carcinogenic risk evaluation
| Project/Area Number |
22310037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
KAMIYA Kenji 広島大学, 原爆放射線医科学研究所, 教授 (60116564)
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| Co-Investigator(Kenkyū-buntansha) |
SASATANI Megumi 広島大学, 原爆放射線医科学研究所, 助教 (80423052)
IIDUKA Daisuke 広島大学, 原爆放射線医科学研究所, 助教 (00455388)
MASUDA Yuji 名古屋大学, 環境医学研究所, 准教授 (30273866)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 低線量放射線 |
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| Research Abstract |
It was explored the development of a biological dosimeter for low dose irradiation using our latest research data about mutagenesis. Rev1 Tg mice and Apc^Min/+mice, which are the model mice for human familial adenomatous polyposis coli, are used to generate Apc^Min/+; Rev1 Tg mice. The incidence of spontaneous and radiation-induced intestinal adenoma in Apc^Min/+; Rev1 Tg mice was significantly higher than that in Apc^Min/+; mice. Apc^Min/+; Rev1 Tg mouse is thought to be useful for the study of risk estimation of radiation-induced cancers.
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[Journal Article] Regulation of DNA Polymerase POLD4 Influences Genomic Instability in Lung Cancer2010
Author(s)
Huang QM, Tomida S, Masuda Y, Arima C, Cao K, Kasahara T, Osada H, Yatabe Y, Akashi T, Kamiya K, Takahashi T, Suzuki M
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Journal Title
Cancer Research
Volume: 70(21)
Pages: 8407-8411
Peer Reviewed
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[Presentation] Function of RAD18 on radioresponse2013
Author(s)
Y. Xu, M. Sasatani, H. Kawai, K. Kamiya
Organizer
The 2nd International Symposium Phoenix Leader Education Program(Hiroshima Initiative) for Renaissance from Radiation Disaster -Suggestion for the Renaissance from Radiation Disaster-
Place of Presentation
Hiroshima
Year and Date
2013-02-10
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[Presentation] 放射線発がんとゲノム不安定性2011
Author(s)
笹谷めぐみ, 徐 衍賓, 本田浩章, 濱崎幹也, 楠 洋一郎, 渡邊敦光, 増田雄司, 神谷研二
Organizer
日本放射線影響学会第54回大会
Place of Presentation
神戸市
Year and Date
2011-11-19
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