2012 Fiscal Year Final Research Report
Molecular mechanism of neuronal cell death induced by methyl mercury via endoplasmic reticulum stress
| Project/Area Number |
22310039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Okayama University |
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Principal Investigator |
UEHARA Takashi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00261321)
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| Project Period (FY) |
2010 – 2012
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| Keywords | メチル水銀 / 一酸化窒素 / 酸化ストレス / 神経細胞 / アポトーシス / 経変性疾患 / シグナル伝達 |
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| Research Abstract |
We found that methyl mercury results in neuronal cell death and the reduction of S-nitrosylated PDI formation in a concentration-dependent manner in SH-SY5Y cells. These observations suggested methyl mercury affects same cysteine residue that is oxidized by nitric oxide. Treatment with methyl mercury stimulated the specific splicing of XBP1 mRNA and phosphorylation of IRE1α. Thus, methyl mercury might induce apoptosis via endoplasmic reticulum stress caused by dysfunction of protein maturation system.
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Research Products
(20 results)
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[Journal Article] Participation of metabotropic glutamate receptors in pentetrazol-induced kindled seizure.2011
Author(s)
Watanabe, Y., Kaida, Y., Fukuhara, S., Takechi, K., Uehara, T., and Kamei, C.
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Journal Title
Epilepsia
Volume: 52
Pages: 140-150
DOI
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[Journal Article] On-off system for PI3-kinase-Akt signaling through S-nitrosylation of PTEN.2011
Author(s)
Numajiri, N., Takasawa, K., Nishiya, T., Tanaka, H., Ohno, K., Hayakawa, W., Asada, M., Matsuda, H., Azumi, K., Kamata, H., Nakamura, T., Hara, H., Minami, M., Lipton, S.A. and Uehara, T
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 108
Pages: 10349-10354
DOI
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[Journal Article] The ECS (SPSB) E3 ubiquitin ligase is the master regulator of the lifetime of inducible nitric-oxide synthase2011
Author(s)
Matsumoto, K., Nishiya, T., Maekawa, S., Horinouchi, T., Ogasawara, K., Uehara, T.,and Miwa, S..
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 409
Pages: 46-51
DOI
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[Journal Article] SPRY domain-containing SOCS box protein-1 (SPSB1), SPSB2, and SPSB4 are master regulators of proteasome-dependent degradation of iNOS2011
Author(s)
Nishiya, T., Matsumoto, K., Maekawa, S., Horinouchi, T., Fujimuro, M., Ogasawara, K., Uehara, T., and Miwa, S
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Journal Title
J. Biol. Chem
Volume: 286
Pages: 9009-9019
DOI
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