2012 Fiscal Year Final Research Report
| Project/Area Number |
22310082
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
TAKADA Kanji 京都薬科大学, 薬学部, 教授 (30102106)
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| Co-Investigator(Renkei-kenkyūsha) |
ITO Yukako 京都薬科大学, 薬学部, 講師 (30278444)
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| Project Period (FY) |
2010 – 2012
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| Keywords | マイクロファブリケーション |
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| Research Abstract |
Two- and three-layered dissolving microneedles was loaded with ovalbumin (OA) at the acral and second portion of the needles. As 3-layered MNs delivered anitigen to Langerhans cells that localize in the epiderm, stronger immunological reaction was induced. On the other hand, the target site of tetanus toxoid was revealed to be the Langerhans cells distributed mainly in the skin epiderm.
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