2013 Fiscal Year Final Research Report
Regulation of gene expression by chromosome condensation protein, condensin
| Project/Area Number |
22310116
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genome biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KIMURA Keiji 筑波大学, 生命環境系, 准教授 (50332268)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 遺伝子発現制御 / クロマチン / コンデンシン / 核小体 |
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| Research Abstract |
ChIP assay indicated that both isoform of condensin (I and II) presented on the rDNA region in the interphase nucleolus. Knockdown of condensin (I or II) led to enhanced acetylation of histones in rRNA region, suggesting that condensin condenses interphase chromatin structures and suppresses gene expressions. We also found that dephosphorylation of condensin (I and II) by PP1 and PP2A at the exit of mitosis was important for dissociation of condensin from mitotic chromosomes.
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Research Products
(15 results)
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[Journal Article] Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factor ERbeta and KLF52011
Author(s)
Nakajima Y, Akaogi K, Suzuki T, Osakabe A, Yamaguchi C, Sunahara N, Ishida R, Kako K, Ogawa S, Fujimura T, Homma Y, Fukamizu A, Murayama A, Kimura K, Inoue S, Yanagisawa J
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Journal Title
Science Signaling
Volume: 4
Pages: ra22
DOI
Peer Reviewed
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[Journal Article] Novel nucleolar pathway connecting intracellular energy status with p53 activation2011
Author(s)
Kumazawa T, Nishimura K, Kuroda T, Ono W, Yamaguchi C, Katagiri N, Tsuchiya M, Masumoto H, Nakajima Y, Murayama A, Kimura K, Yanagisawa J
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Journal Title
J. Biol. Chem.
Volume: 288
Pages: 20861-20869
Peer Reviewed
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