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2012 Fiscal Year Final Research Report

Development of novel methods for sequence comparison in the era of massive DNA sequencing data

Research Project

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Project/Area Number 22310124
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field System genome science
Research InstitutionNational Institute of Advanced Industrial Science and Technology (2012)
Kyoto University (2010-2011)

Principal Investigator

GOTOH Osamu  独立行政法人産業技術総合研究所, 生命情報工学研究センター, 招聘研究員 (40142111)

Co-Investigator(Kenkyū-buntansha) ICHINOSE Natsuhiro  京都大学, 情報研究科, 助教 (70302750)
Project Period (FY) 2010 – 2012
Keywords次世代シークエンサー / アラインメント / ゲノム / RNA-Seq / 比較ゲノム / スプライシング / アルゴリズム / アセスメント
Research Abstract

We focused on middle-to-long DNA reads generated by new generation sequencers, and developed a computer program named “Spaln” that maps and spliced-align a set of transcripts onto reference genomic sequences. When tested on full length cDNA or protein ami

  • Research Products

    (23 results)

All 2013 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (14 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Heuristic Alignment Methods, Methods in Molecular Biology2013

    • Author(s)
      Gotoh, O
    • Journal Title

      Russel, D. ed

      Volume: (in press)

  • [Journal Article] Evolution of cytochrome P450 genes from the viewpoint of genome informatics2012

    • Author(s)
      Gotoh, O
    • Journal Title

      Biol. Pharm. Bull

      Volume: 35 (6) Pages: 812-817

    • DOI

      DOI:10.1248/bpb.35.812

    • Peer Reviewed
  • [Journal Article] Benchmarking spliced alignment programs including Spaln2, an extended version of Spaln that incorporates additional species-specific features2012

    • Author(s)
      Iwata, H. and Gotoh, O
    • Journal Title

      Nucleic Acids Res

      Volume: 40 (20) Pages: e161

    • DOI

      DOI:10.1093/nar/gks708

    • Peer Reviewed
  • [Journal Article] Identification of a new clock-related element EL-box involved in circadian regulation by BMAL1/CLOCK and HES12012

    • Author(s)
      Ueshima, T., Kawamoto, T., Honda, K.K, Noshiro, M., Fujimoto, K., Nakao, S., Ichinose, N., Hashimoto, S., Gotoh, O., Kato, Y
    • Journal Title

      Gene

      Volume: 510 (2) Pages: 118-125

    • DOI

      DOI:10.1016/j.gene.2012.08.022

    • Peer Reviewed
  • [Journal Article] A large-scale motif discovery using a DNA Gray code and equiprobable oligomers2012

    • Author(s)
      Ichinose, N., Yada, T., Gotoh, O
    • Journal Title

      Bioinformatics

      Volume: 28 (1) Pages: 25-31

    • DOI

      DOI:10.1093/bioinformatics/btr606

    • Peer Reviewed
  • [Journal Article] Comparative analysis of information contents relevant to recognition of introns in many species2011

    • Author(s)
      Iwata, H. and Gotoh, O
    • Journal Title

      BMC Genomics

      Volume: 12 Pages: 45

    • DOI

      DOI:10.1186/1471-2164-12-45

    • Peer Reviewed
  • [Journal Article] Cgaln: fast and space-efficient whole-genome alignment2010

    • Author(s)
      Nakato, R. and Gotoh, O
    • Journal Title

      BMC Bioinformatics

      Volume: 11 Pages: 224

    • DOI

      DOI:10.1186/1471-2105-11-224

    • Peer Reviewed
  • [Presentation] Detection of splice junctions from mid-to-long RNA-seq reads by Spaln2012

    • Author(s)
      Zeng, C., Iwata, H., Ichinose, N., Yata, T., Gotoh, O
    • Organizer
      GIW 2012
    • Place of Presentation
      National Cheng Kung University, Tainan, Taiwan
    • Year and Date
      20121212-14
  • [Presentation] Mapping middle-to-long RNA-seq reads onto genomic sequence2012

    • Author(s)
      Zeng, C., Iwata, H., Gotoh, O
    • Organizer
      JSBi 2012
    • Place of Presentation
      タワーホール船堀, Tokyo(東京都)
    • Year and Date
      20121015-17
  • [Presentation] Gene-structure-aware multiple protein sequence alignment as a tool for assessment of predicted eukaryotic gene structures2012

    • Author(s)
      Gotoh, O. and Morita, M
    • Organizer
      JSBi 2012
    • Place of Presentation
      タワーホール船堀, Tokyo(東京都)
    • Year and Date
      20121015-17
  • [Presentation] The examination of enhanced diversity in the substrate recognition sites of P4502012

    • Author(s)
      Morita, M. and Gotoh, O
    • Organizer
      The Regional Museum of Natural Sciences - Turin
    • Place of Presentation
      Torino, Italy
    • Year and Date
      20120622-26
  • [Presentation] Comparison of two strategies for comprehensive identification of P450 genes on multiple eukaryotic genomes, Cytochrome P450 Biodiversity and Biotechnology2012

    • Author(s)
      Gotoh, O. and Morita, M
    • Organizer
      The Regional Museum of Natural Sciences -Turin
    • Place of Presentation
      Torino, Italy
    • Year and Date
      20120622-26
  • [Presentation] Evaluation of Spliced Alignment Programs using Cross-Species Benchmark Datasets2011

    • Author(s)
      Iwata, H. and Gotoh, O
    • Organizer
      JSBi 2010
    • Place of Presentation
      神戸国際会議場, Kobe(兵庫県)
    • Year and Date
      20110000
  • [Presentation] 配列アラインメントのこれまでとこれから2011

    • Author(s)
      後藤修
    • Organizer
      CBI/JSBi 合同大会
    • Place of Presentation
      神戸国際会議場, 神戸(兵庫県)
    • Year and Date
      2011-11-10
  • [Presentation] ゲノム上の分布から見た P450 遺伝子族の進化2011

    • Author(s)
      後藤 修
    • Organizer
      日本生化学会
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2011-09-24
  • [Presentation] Evaluation of Spliced Alignment Programs Including an Extended Version of Spaln2010

    • Author(s)
      Iwata, H. and Gotoh, O
    • Organizer
      JSBi
    • Place of Presentation
      九州大学医学部百年講堂, Fukuoka(福岡県)
    • Year and Date
      20101213-15
  • [Presentation] Memory Management of Pairwise Alignment Using Garbage Collection2010

    • Author(s)
      Ichinose, N., Yada, T. and Gotoh, O
    • Organizer
      JSBi
    • Place of Presentation
      九州大学医学部百年講堂,, Fukuoka(福岡県)
    • Year and Date
      20101213-15
  • [Presentation] RDF Curator: A Novel Workflow that Generates Semantic Graph from Literature for Curation Using Text Mining2010

    • Author(s)
      Komiyama, Y. and Gotoh, O
    • Organizer
      Proc. Biocuration 2010,International Society for Biocuration
    • Place of Presentation
      AIST Waterfront Bio-IT Research Building, Tokyo(東京都)
    • Year and Date
      20101011-14
  • [Presentation] A Method for fast and space-efficient whole-genome sequence alignment, in Proceeding of the 5th International Conference2010

    • Author(s)
      Nakato, R. and Gotoh, O
    • Organizer
      "Genomics, Proteomics, Bioinformatics and Nanobiotechnology for Medicine" GPBNM-2010
    • Place of Presentation
      St. Petersburg, Russia
    • Year and Date
      20100531-0605
  • [Presentation] Comparative analysis of information contents relevant to intron recognition in many species2010

    • Author(s)
      Iwata, H. and Gotoh, O
    • Organizer
      3rd Asian Young Researchers Conference for Computational and Omics Biology
    • Place of Presentation
      National Cheng Kung University, Tainan, Taiwan
    • Year and Date
      20100310-12
  • [Presentation] A Related Graph Generation System for Biomass Data and Its Evaluation by Comparison with Manual Curation2010

    • Author(s)
      Komiyama, Y. and Gotoh, O
    • Organizer
      JSBi
    • Place of Presentation
      Fukuoka(福岡県)
    • Year and Date
      20100000
  • [Book] バイオインフォマティクス2011

    • Author(s)
      後藤修
    • Publisher
      シュプリンガージャパン
  • [Remarks]

    • URL

      http://www.genome.ist.i.kyoto-u.ac.jp/aligner.php

URL: 

Published: 2014-08-29  

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