2012 Fiscal Year Final Research Report
Search for Natural Products which Enhance the Function of TumorSuppressor Protein and Study of the Mechanisms of Effects
| Project/Area Number |
22310138
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOKOSAWA Hideyoshi 愛知学院大学, 薬学部, 教授 (90012765)
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| Project Period (FY) |
2010 – 2012
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| Keywords | がん抑制遺伝子産物 / 天然低分子化合物 / ユビキチン / プロテアソーム / 抗がん剤 / 海洋生物 |
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| Research Abstract |
Compounds, which enhance the function of tumor suppressor p53,are promising anti-cancer leads. We search for the compounds from natural sources. Sofar we reported the inhibitors of E1, E2, and E3, which function for the polyubiquitinationof target proteins. In this project, we search for inhibitors of the recruitment of thepolyubiquitinated p53 for the cancer treatment.
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