2012 Fiscal Year Final Research Report
Chemical Biology on Cancer and Neurodegenerative disease
| Project/Area Number |
22310140
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
IMOTO Masaya 慶應義塾大学, 理工学部, 教授 (60213253)
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| Project Period (FY) |
2010 – 2012
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| Keywords | CysLT1アンタゴニスト / がん転移 / オートファジー / パーキンソン疾患 |
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| Research Abstract |
1）We showed that SO286 inhibited protein aggregation induced by MPP+ through lysosomal degradation pathway. We attempted to identify the target protein of SO286 responsible for the mechanism of SO286 inhibited the MPP+-induced dot formation and regulation
2）We report that 5-lipoxygenase (5-LOX) is activated and produces leukotriene C4(LTC4) in the process of cell migration, and 5-LOX inhibitors suppressed cell migration. Next, we identified cysteinyl leukotoriene receptor 1 (CysLT1) antagonist also block c
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[Journal Article] Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells2012
Author(s)
Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M, Iida S
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Journal Title
as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J.e
Volume: 79
Peer Reviewed
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[Journal Article] Comprehensive Predictions of Target Proteins Based on Protein-Chemical Interaction Using Virtual Screening and Experimental Verifications2012
Author(s)
Kobayashi H, Harada, H, Nakamura M, FutamuraY, Ito A, Yoshida M, Iemura S, Shin-ya K, Doi T, Takahashi T, Natsume T, Imoto Mand Sakakibara Y
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Journal Title
BMC Chemical Biology
Volume: 12
Pages: 2
Peer Reviewed
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[Journal Article] Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor2012
Author(s)
Kiga M, Tanzawa F, Iwasaki S, Inaba F, Fujiwara K, IwadareH, Echigo T, Nakamura Y, Shibata T, Suzuki K, Yasumatsu, I Nakayama A, Sasazawa Y, Tashiro E, Imoto M, S. Kurakata S
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Journal Title
SMK-17. Anticancer Drugs.
Volume: 23
Pages: 119-130
Peer Reviewed
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[Journal Article] Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition2011
Author(s)
Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Kei-Ichi Ishikawa, Sato S, Imoto M, Hattori N
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Journal Title
Autophagy
Volume: 7
Pages: 42-53
Peer Reviewed
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[Journal Article] Total Synthesis of Incednam, the Aglycon of Incednine2010
Author(s)
T. Ohtani, S. Tsukamoto, H. Kanda, K. Misawa, Y. Urakawa, T. Fujimaki, M. Imoto,Y. Takahashi, D. Takahashi†, and K. Toshima
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Journal Title
Org. Lett
Volume: 12
Pages: 5068-5071
Peer Reviewed
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[Journal Article] Isolation and structure elucidation of a novel androgen antagonist2010
Author(s)
Kawamura T, Fujimaki T, Hamanaka N, Torii K, Kobayashi H, Takahashi Y, Igarashi M, Kinoshita N, Nishimura Y, Tashiro E, Imoto M
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Journal Title
arabilin, produced by Streptomycessp. MK756-CF1. J. Antibiot.
Volume: 63
Pages: 601-605
Peer Reviewed
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[Journal Article] Glyoxalase-I is a novel target against Bcr-Abl+leukemic cells acquiring stem-like characteristics in hypoxic environment2010
Author(s)
Takeuchi M, Kimura S, Kuroda J, Ashihara E, KawataniM, Osada H, Umezawa K, Yasui E, Imoto M, Tsuruo T, Yokota A, Tanaka R, Nagao T, Nakahata N, Fujiyama Y Maekawa T
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Journal Title
Cell Death Diff.
Volume: 17
Pages: 1211-1220
Peer Reviewed
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