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2012 Fiscal Year Final Research Report

Phisiopsychological studies on the function and mechanisms of intrinsic, learned and physiological reward

Research Project

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Project/Area Number 22330205
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental psychology
Research Institution公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011)

Principal Investigator

WATANABE Masataka  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 特任研究員 (50092383)

Co-Investigator(Kenkyū-buntansha) KODAMA Tohru  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 副参事研究員 (20195746)
Co-Investigator(Renkei-kenkyūsha) HONNDA Yoshiko  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 (50142154)
KOJIMA Takashi  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主任研究員 (30225429)
SAKAGAMI Masamichi  玉川大学, 脳科学研究所, 教授 (10225782)
TSUTSUI Ken-ichiro  東北大学, 大学院・生命科学研究科, 准教授 (90396466)
Project Period (FY) 2010 – 2012
Keywords生理的報酬 / 学習獲得的報酬 / 内発的報酬 / 線条体 / 前頭連合野 / ニューロン活動 / 神経伝達物質
Research Abstract

As reinforcers that strengthen learned responses, there are three different kinds of rewards (physiological, learned and intrinsic). We showed that physiological or learned rewards have different significance on the monkey depending on the social or intrinsic context in relation to whether they are delivered in the competitive situation or not, and demonstrated that monkey prefrontal neurons responded differently to the reward depending on the social context. We also showed that the magnitude of dopamine release in the monkey prefrontal cortex differed depending on whether the reward was delivered during the learning situation or not.

  • Research Products

    (22 results)

All 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (13 results) Book (5 results)

  • [Journal Article] Prefrontal neurons represent winning and losing during competitive video shooting games between monkeys2012

    • Author(s)
      Hosokawa T, Watanabe M
    • Journal Title

      Journal of Neuroscience

      Volume: 32(22) Pages: 7662.7671

    • DOI

      DOI:10.1523/JNEUROSCI.6479-11.2012

    • Peer Reviewed
  • [Journal Article] デフォルト脳活動2011

    • Author(s)
      渡辺正孝
    • Journal Title

      Clinical Neuroscience

      Volume: 29(11) Pages: 1314-1315

  • [Journal Article] 脳活動から見える動物のこころ2011

    • Author(s)
      渡辺正孝
    • Journal Title

      動物心理学研究

      Volume: 61(2) Pages: 131-139

    • DOI

      DOI:10.2502/janip.61.2.1

    • Peer Reviewed
  • [Journal Article] Do monkeys think? Default brain activity in humans and nonhuman primates2011

    • Author(s)
      Watanabe M
    • Journal Title

      Behavioral Brain Research

      Volume: 221 Pages: 295.303

    • DOI

      DOI:10.1016/j.bbr.2011.02.032

    • Peer Reviewed
  • [Presentation] 情動の制御と脳の可塑性2012

    • Author(s)
      渡辺正孝
    • Organizer
      第2回日本情動学会
    • Place of Presentation
      慶応大学三田キャンパス
    • Year and Date
      2012-12-22
  • [Presentation] Dopamine release in the prefrontal cortex is paradoxically smaller when preferred rather than non-preferred reward is delivered during a working memory task . a monkey microdialysis study2012

    • Author(s)
      Kodama T, Hikosaka K, Honda Y, Kojima T, Watanabe M
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-11-17
  • [Presentation] Increase of dopamine release in the prefrontal cortex and striatum by oral administration of methylphenidate - a microdialysis study in the monkey2012

    • Author(s)
      Kojima T, Kodama T, Honda Y, Watanabe M
    • Organizer
      第31回神経科学学術集会発表
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-09-19
  • [Presentation] Decision making and Representation of Motivational Value in the Primate Prefrontal Cortex. In "Neuronal, computational, and cognitive underpinnings of Dynamic decision making"2012

    • Author(s)
      Watanabe M
    • Organizer
      Invited speaker in the symposium of The Annual Meeting of the Cognitive Science Society
    • Place of Presentation
      Sapporo
    • Year and Date
      2012-08-04
  • [Presentation] 認知・注意集中の前頭葉メカニズム2012

    • Author(s)
      渡辺正孝
    • Organizer
      日本睡眠学会第37回定期学術集会 シンポジュウム 「覚醒を考える―awake;arousal、attention、そしてcognition―」招待講演
    • Place of Presentation
      横浜国際会議場
    • Year and Date
      2012-08-04
  • [Presentation] Oral administration of methylphenidate increases dopamine release in the prefrontal cortex and striatum in the monkey - a microdialysis study2011

    • Author(s)
      Kojima T, Kodama T, Honda Y, Hosokawa T, Watanabe M
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-14
  • [Presentation] サルにおけるデフォルト脳活動2011

    • Author(s)
      渡辺正孝
    • Organizer
      生理研社会神経科学研究会「今、社会神経科学研究に求められていること」招待講演
    • Place of Presentation
      生理学研究所 岡崎
    • Year and Date
      2011-10-06
  • [Presentation] 「サルのデフォルト脳活動」 「脳とこころのメカニズム」2011

    • Author(s)
      渡辺正孝
    • Organizer
      第11回冬のワークショップ 招待講演
    • Place of Presentation
      北海道ルスツ
    • Year and Date
      2011-01-13
  • [Presentation] Differential activity of monkey anterior cingulate neurons depending on the rival's identity and animacy during competitive games2010

    • Author(s)
      Kuwajima M, Hosokawa T, Kodama T, Watanabe M
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2010-11-17
  • [Presentation] Irrational reward contingency in the competitive video game suppresses outcome-related prefrontal neuronal activity in the monkey2010

    • Author(s)
      Hosokawa T, Watanabe M
    • Organizer
      40th Society for Neuroscience Meeting
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2010-11-15
  • [Presentation] 認知神経科学領域における社会脳-動物の社会行動と脳内報酬系2010

    • Author(s)
      渡辺正孝
    • Organizer
      日本心理学会第74回大会 シンポジュウム「社会脳」
    • Place of Presentation
      大阪大学豊中キャンパス
    • Year and Date
      2010-09-21
  • [Presentation] 脳活動からみえる動物のこころ2010

    • Author(s)
      渡辺正孝
    • Organizer
      日本動物心理学会第70回大会 特別講演
    • Place of Presentation
      帝京大学
    • Year and Date
      2010-08-28
  • [Presentation] Prefrontal neuronal activity in the monkey during competitive and noncompetitive video shooting games2010

    • Author(s)
      Watanabe M, Hosokawa T
    • Organizer
      15th Biennial Scientific Meeting of the International Society for Comparative Psychology, 招待講演
    • Place of Presentation
      Awaji-Yumebutai International Conference Center, Hyogo
    • Year and Date
      2010-05-20
  • [Book] サルに内的思考過程は存在するか? - サルにおけるデフォルト脳活動 シリーズ社会脳、第1巻、「社会神経科学の展望--脳から社会をみる」 苧阪直行編2012

    • Author(s)
      渡辺正孝
    • Total Pages
      145-162
    • Publisher
      新曜社
  • [Book] How context impacts cognitive and motivational control of behavior in the primate prefronal cortex (In Stuss DT & Knight RT eds. Principles of Frontal Lobe Function, 2nd Edition)2012

    • Author(s)
      Watanabe M
    • Total Pages
      211-255
    • Publisher
      Oxford University Press
  • [Book] 翻訳 行動の機構--脳メカニズムから心理学へ(D.O.ヘッブ 著),(下), 担当:第10章、情動障害2011

    • Author(s)
      鹿取 廣人, 金城 辰夫, 鈴木 光太郎, 鳥居 修晃, 渡辺正孝
    • Total Pages
      114-185
    • Publisher
      岩波文庫
  • [Book] 発想の大脳メカニズ 「発想と企画の心理学」(高橋誠編), 第1章2010

    • Author(s)
      渡辺正孝
    • Total Pages
      14-27
    • Publisher
      朝倉書店
  • [Book] 快・不快と報酬 - 生理的報酬と内発的報酬(苧阪直行編 「報酬を期待する脳」)

    • Author(s)
      渡辺正孝
    • Publisher
      新曜社(印刷中)

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Published: 2014-08-29   Modified: 2015-09-15  

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