2013 Fiscal Year Final Research Report
Development of atmospheric-pressure laser desorption/ionization technique using nanoparticles and nanostructural surfaces
| Project/Area Number |
22350040
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Kansai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Hideya 関西大学, 化学生命工学部, 教授 (50322285)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | ナノ粒子 / レーザー脱離イオン化 / SALDI-MS / アフィニテーSALDI-MS / MSイメージング / 局在表面プラズモン共鳴 |
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| Research Abstract |
Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using nanoparticles and nanostructured surfaces, as compared to matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) using organic matrices, affords low-noise background (<500 Da). In this study, new atmospheric pressure(AP)-SALDI-MS was developed to achieve easily high-throughput analysis for low molecular weight compounds such as pollutants in environment, pharmaceutical products, and industry materials. Novel nanostructured surfaces and nanoparticle aggregates were designed to study effectiveness on AP-SALDI. The ionization mechanism of AP-SALDI is elucidated, compared with vacuum-SALDI. We could propose three new MS applications; 1) a complementary analytical methodology combining localized surface plasmon resonance (LSPR) sensing with SALDI-MS, 2) affinity SALDI-MS using magnetic nanoparticle, and 3) platinum vapor deposition SALD-MS imaging for small molecules.
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