2013 Fiscal Year Final Research Report
New Development of Catalytic Fluoroalkylation
| Project/Area Number |
22350043
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
AMII Hideki 群馬大学, 理工学研究科, 教授 (00284084)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Masahiko 神戸大学, 大学院理学研究科, 教授 (60192704)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 有機合成化学 / クロスカップリング / フッ素 / トリフルオロメチル化 / 有機金属化学 / 銅 / 触媒 / 選択的変換 |
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| Research Abstract |
Organofluorine compounds are the substances of considerable interest in various industrial fields due to their unique physical and chemical properties. Among them, trifluoromethylated aromatic compounds (Ar-CF3) are the substances of considerable interest in various industrial fields. Owing to the increasing demands for fluoroaromatics, new methodologies for aromatic trifluoromethylation have been required from the viewpoints of cost, simplicity, efficiency, versatility, and environmental benignity including a catalytic process. We have succeeded in the development of a catalytic procedure for aromatic trifluoromethylation by the use of trifluoroacetaldehyde hemiaminal derivatives as readily available cross-coupling partners. Furthermore, we have developed reaction sequences leading to efficient synthesis of difluoromethylated aromatics (Ar-CF2H) and monofluoromethylated aromatics (Ar-CFH2) via 2-aryl-2,2-difluoroacetates.
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Research Products
(48 results)
