2013 Fiscal Year Final Research Report
Design of nano-capsules having controlled degradability by dendrimer precision synthesis.
| Project/Area Number |
22350048
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
AOI Keigo 名古屋大学, 生命農学研究科, 教授 (30222467)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMI Noriyoshi 名古屋大学, 大学院生命農学研究科, 准教授 (40323745)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | デンドリマー / リビング重合 / 超分子化学 / ナノ材料 / 構造制御 / 精密高分子 / 分子カプセル / 感温特性 |
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| Research Abstract |
In the present project, we successfully synthesized an aliphatic polyester dendrimer using AB2-type building blocks prepared by Michael addition of denzyl acetoacetate to t-butyl acrylate, followed by reduction and by deprotection of the t-butyl groups. The aliphatic polyester dendrimer is a candidate of smart nano-materials having controlled degradability and release function of low-molecular-weight compounds.
We also syntesized a new type of thermoresponsive star-type dendrimers having oligo(2-isopropyl-2-oxazoline) side chains and oligo(2-alkyl-2-oxazoline) terpolymer side chains, by precision polymer syntheses. Lower critical solution temperatures (LCSTs) and release profiles of the loaded low-molecular-weight compounds of the resulting star-type dendrimers are successfully controlled with changing the chemical structure, especially the arm structure. These star-type dendrimers are useful functional nano-materials in biochemical and biomedical fields.
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