2012 Fiscal Year Final Research Report
Preparation of thermo-responsive nano-carrier which can solubilize fullerene complex as a photosensitizer in water
| Project/Area Number |
22350106
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer/Textile materials
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| Research Institution | University of Hyogo |
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Principal Investigator |
YUSA Shin-ichi 兵庫県立大学, 工学研究科, 准教授 (00301432)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASE Takeshi 兵庫県立大学, 工学研究科, 教授 (10201443)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGO Shigeru 京都大学, 化学研究所, 教授 (30222368)
KOMADA Fusao 姫路独協大学, 薬学部, 教授 (50306247)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 精密ラジカル重合 / 高分子構造・物性 / ナノチューブ・フラーレン / ナノ材料 / 光物性 / 光線力学的療法 / 温度応答性 / 自己集合体 |
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| Research Abstract |
Water-soluble diblock copolymer, poly(N-isopropylacrylamide)-block-poly(N-vinyl-2-pyrroridone) (PNIPAMm-b-PNVPn), was found to associate with fullerene (C_60), and thus C_60 can be solubilized in water. The C_60/PNIPAMm-b-PNVPn micelle formed an aggregate comprising a C_60/PNVP hydrophobic core and a thermoresponsive PNIPAM shell. The hydrodynamic radius of the C_60-bound polymer micelle increased with increasing temperature, which was ascribed to the hydrophobic association between dehydrated PNIPAM shells above lower critical solution temperature. The generation of singlet oxygen by photosensitization by the C_60-bound polymer micelle was confirmed from photooxidation of 9,10-anthracenedipropionic acid. Furthermore, DNA was found to be cleaved by visible light irradiation in the presence of the C_60-bound polymer micelle. Therefore, there may be a hope for a pharmaceutical application of the C_60-bound polymer micelle to cancer photodynamic therapy (PDT).
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Research Products
(42 results)
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[Journal Article] Novel LaBO_3 hollow nanospheres of size 34 ± 2 nm templated by polymeric micelles2012
Author(s)
M. Sasidharan, N. Gunawardhana, N. Gunawardhana, H. N. Luitel, T. Yokoi, M. Inoue, S. Yusa, T. Watari, M. Yoshio, T. Tatsumi, K. Nakashima
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Journal Title
Journal of Colloid and Interface Science
Volume: 370
Pages: 51-57
Peer Reviewed
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[Remarks] アウトリーチ活動1) 2010年青少年のための科学の祭典、2010年8月7～8日、「不思議な石と面白い鉄」(姫路会場)
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[Remarks] アウトリーチ活動2) 2011年青少年のための科学の祭典、2011年8月6～7日、「お湯に溶けやすい?それとも溶けにくい?」(姫路会場)
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[Remarks] アウトリーチ活動3) 「電気の不思議を体験しよう」、2012年1月28日、2月24日(兵庫県立大学書写キャンパス)
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[Remarks] アウトリーチ活動4) 2012年青少年のための科学の祭典、2012年8月11～12日、「水上でスケートする水滴」(姫路会場)
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