2012 Fiscal Year Final Research Report
Localized surface plasmon sensing for detection and diagnosis of influenza viruses
| Project/Area Number |
22360022
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied optics/Quantum optical engineering
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| Research Institution | Muroran Institute of Technology |
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Principal Investigator |
KANO Hiroshi 室蘭工業大学, 工学研究科, 准教授 (80322874)
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| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Hideki 国立感染症研究所, 感染病理部, 部長 (30301790)
MORIGAKI Kenichi 神戸大学, 遺伝子実験センター, 准教授 (10358179)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 光計測 / 表面プラズモン / 屈折率計測 / ウイルス |
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| Research Abstract |
A method to determine subtype of influenza viruses by using surface plasmons localized in microscopic region on a flat metal surface was developed. In this method, refractive index variation arisen from interactions between viruses and their monoclonal antibodies was measured. Theoretical calculation revealed that measurement region had a size of ～180nm in radius, and could be occupied by ～7 viruses. The detection of influenza viruses with certain subtype was successfully demonstrated.
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[Journal Article] Characterization of neutralizing antibodies in adults after intranasal vaccination with an inactivated influenza vaccine2012
Author(s)
A. Ainai, S. Tamura, T. Suzuki, R. Ito, H. Asanuma, T. Tanimoto, Y. Gomi, S. Manabe, T. Ishikawa, Y. Okuno, T. Odagiri, M. Tashiro, T. Sata, T. Kurata, H. Hasegawa
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Journal Title
J. Med. Virol.
Pages: 336-344
DOI
Peer Reviewed
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[Journal Article] Pathological study of archival lung tissues from five fatal cases of avian H5N1 influenza in Vietnam2012
Author(s)
N. Nakajima, N. Van Tin, Y. Sato, HN Thach, H. Katano, PH Diep, T. Kumasaka, NT Thuy, H. Hasegawa, LT San, S. Kawachi, NT Liem, K. Suzuki, T. Sata
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Journal Title
Mod. Pathol.
Pages: 357-369
DOI
Peer Reviewed
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