Understanding of light propagation inside human heads and improvement of optical mapping images based on the radiative transfer

2012 Fiscal Year Final Research Report

• Project/Area Number: 22360087
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thermal engineering
• Research Institution: The University of Electro-Communications
• Principal Investigator: YAMADA Yukio 電気通信大学, 大学院・情報理工学研究科, 教授 (10334583)
• Co-Investigator(Kenkyū-buntansha): YOKOI Hiroshi 電気通信大学, 大学院・情報理工学研究科, 教授 (90271634) ; HOSHI Yoko (財)東京都医学総合研究所, ヒト統合脳機能プロジェクト, プロジェクトリーダー (50332383) ; OKAWA Shinpei 防衛医科大学校, 医学教育部・医学科専門課程, 助教 (20432049) ; TANIKAWA Yukari (独)産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 主任研究員 (20344202)
• Project Period (FY): 2010 – 2012
• Keywords: 輻射 / 生体光学

Research Abstract

For the purpose of the improvement of optical mapping technology which images brain functions noninvasively using near-infrared light, numerical simulations based on the analysis of light propagation in heads and phantom experiments were conducted. The effects of the non-scattering tissues such as the cerebrospinal fluid layer, eye ball and frontal sinus on the mapping images were investigated. Also the effects of the thick blood vessels lying at the brain surface were investigated. The results will contribute to better understanding of the mapping images and to improvement of the quality of the mapping images.

Research Products

• [Journal Article] Phantom and mouse experiments of time-domain fluorescence tomography using total light approach (2013)
  • Author(s): S. Okawa, A. Yano, K. Uchida, Y. Mitsui, M. Yoshida, M. Takekoshi, A. Marjono, F. Gao, Y. Hoshi, I. Kida, K. Masamoto, and Y. Yamada
  • Journal Title: Biomedical Optics Express Volume: Vol.4 Pages: 635-651
  • DOI: DOI:10.1364/BOE.4.000635
  • Peer Reviewed
• [Journal Article] 硬膜下電位からのサル捕食運動中の状態判別とロボットアーム動作決定 (2013)
  • Author(s): 佐藤圭太,森下壮一郎,加藤龍,横井浩史,梅田達也,渡辺秀典,西村幸男,伊佐正
  • Journal Title: 日本ロボット学会誌 Volume: Vol.31 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Reduction of Poisson noise in measured time-resolved data for time-domain diffuse optical tomography (2012)
  • Author(s): S. Okawa, Y. Endo, Y. Hoshi and Y. Yamada
  • Journal Title: Medical&Biological Engineering&Computing Volume: Vol.50 Pages: 69-78
  • DOI: DOI:10.1007/s11517-011-0774-7
  • Peer Reviewed
• [Journal Article] The role of the prefrontal cortex in the cognitive control of reaching movements - a near-infrared spectroscopy study (2011)
  • Author(s): K. Goto, Y. Hoshi, M. Sata, M. Kawahara, M. Takahashi, M. Murohashi
  • Journal Title: Journal of Biomedical Optics Volume: Vol.16 No. 127003
  • DOI: DOI:10.1117/1.3658757
  • Peer Reviewed
• [Journal Article] Reduction of image artifacts induced by change in the optode coupling in time-resolved diffuse optical tomography (2011)
  • Author(s): R. Fukuzawa, S. Okawa, S. Matsuhashi, T. Kusaka, Y. Tanikawa, Y. Hoshi, F. Gao, and Y. Yamada
  • Journal Title: Journal of Biomedical Optics Volume: Vol. 16, No. 116022
  • DOI: DOI:10.1117/1.3653236
  • Peer Reviewed
• [Journal Article] Improvement of image quality of time-domain diffuse optical tomography with lp sparsity regularization (2011)
  • Author(s): S. Okawa, Y. Hoshi and Y. Yamada
  • Journal Title: Biomedical Optics Express Volume: Vol.2 Pages: 3334-3348
  • DOI: DOI:10.1364/BOE.2.003334
  • Peer Reviewed
• [Journal Article] Recognition of human emotions from cerebral blood flow changes in the frontal region: a study with event-related near-infrared spectroscopy (2011)
  • Author(s): Y. Hoshi, J. Huang, S. Kohri, Y. Iguchi, M. Naya, T. Okamoto, S. Ono
  • Journal Title: Journal of Neuroimaging Volume: Vol.21 Pages: e94-e101
  • DOI: DOI:10.1111/j.1552-6569.2009.00454.x.
  • Peer Reviewed
• [Journal Article] Effects of spatial variation of skull and cerebrospinal fluid layers on optical mapping of brain activities (2010)
  • Author(s): S. Wang, N. Shibahara, D. Kuramashi, S. Okawa, N. Kakkuta, E. Okada, Atsushi Maki, and Y. Yamada
  • Journal Title: Optical Review Volume: Vol. 17 Pages: 410-420
  • Peer Reviewed
• [Journal Article] Effective optode configuration for the image reconstruction in diffuse optical tomography (2010)
  • Author(s): K. Uchida, S. Okawa, S. Matsuhashi, Y. Hoshi and Y. Yamada
  • Journal Title: Medical Laser Application Volume: Vol.25 Pages: 154-160
  • DOI: DOI:10.1016/j.mla.2010.04.003
  • Peer Reviewed
• [Presentation] Influences of Blood Flow Changes in Cerebrospinal Fluid and Skin Layers on Optical Mapping (2013)
  • Author(s): S. Wang, Y. Hoshi, and Y. Yamada
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20130703-07
• [Presentation] The Effects of Delay Time Elements in Myoelectric Prosthetic Hand (2012)
  • Author(s): T. Nakamura, R. Kato and H. Yokoi
  • Organizer: SICE Annual Conference2012
  • Place of Presentation: Akita, Japan
  • Year and Date: 20120820-23
• [Presentation] Cerebral vasoreactivity to carbon dioxide and neural activation in schizophrenia: a study with near-infrared time resolved spectroscopy (2012)
  • Author(s): Y. Hoshi, I. Kida, Y. Iguchi, M. Itokawa, S.Kohno
  • Organizer: 2nd Functional near-infrared spectroscopy conference
  • Place of Presentation: London, UK
  • Year and Date: 2012-10-27
• [Presentation] 光 マッピング画像におよぼす頭部構造の影響に関するファントム実験 (2012)
  • Author(s): 大川晋平,鄭楠,畑裕喜,山田幸生
  • Organizer: 第15回日本光脳機能イメージング研究会
  • Place of Presentation: 東京都
  • Year and Date: 2012-07-28
• [Presentation] 光マッピング画像に及ぼす頭部構造の影響および拡散光トモグラフィーについて (2012)
  • Author(s): 山田幸生
  • Organizer: 第15回日本光脳機能イメージング研究会
  • Place of Presentation: 東京都
  • Year and Date: 2012-07-28
• [Presentation] 上腕高位切断者のための上腕筋電義手の開発-ニューラルネットワークを用いた筋電位信号による方向識別 (2011)
  • Author(s): 佐久間遥, 關達也, 中村達弘, 加藤龍, 横 井浩史, 本多敏
  • Organizer: 生活生命支援医療福祉工学系学会連合大会2011
  • Place of Presentation: 東京都
  • Year and Date: 20111103-05
• [Presentation] Effect of the Arrangement of Optodes For 3D Diffuse Optical Tomography (2011)
  • Author(s): K. Uchida, S. Okawa, K. Mmasamoto, Y. Hoshi and Y. Yamada
  • Organizer: ASME/JSME 2011 8th Thermal Engineering Joint Conference (AJTEC2011)
  • Place of Presentation: Honolulu,USA
  • Year and Date: 20110313-17
• [Presentation] 生体内光伝播と拡散光・蛍光トモグラフィー (2011)
  • Author(s): 山田幸生
  • Organizer: 日本光学会生体医用光学研究会
  • Place of Presentation: 東京都
  • Year and Date: 2011-12-03
• [Presentation] Towar d the next generation of NIR S (2010)
  • Author(s): Y. Hoshi
  • Organizer: The Royal Society Theo Murphy International Science Meeting
  • Place of Presentation: Chicheley, UK
  • Year and Date: 2010-11-08
• [Presentation] 光マッピングへの頭部構 造の影響 (2010)
  • Author(s): 冨樫陵,王淑萍,星詳子,大川晋平,正本和人,山田幸生
  • Organizer: 第13回日本光脳機能イメージ ング研究会
  • Place of Presentation: 東京都
  • Year and Date: 2010-07-24
• [Book] NIRS-基礎と臨床- (2012)
  • Author(s): 星詳子
  • Total Pages: 33-38,45-54, 82-85, 103-107, 164-168
  • Publisher: 新興医学出版社
• [Book] 医用画像工学ハンドブック (2012)
  • Author(s): 山田幸生
  • Total Pages: 371-383
  • Publisher: 日本医用画像工学会編
• [Book] Advances in Therapeutic Engineering (2012)
  • Author(s): H. Yokoi, K. Sato, S. Morishita, T. Nakamura, R. Kato, T. Umeda, H. Watanabe, Y. Nishimura, T. Isa, K. Ikoma, T. Miyamoto, O. Yamamura
  • Total Pages: 219-250
  • Publisher: Taylor & Francis Group anInformation Business