2013 Fiscal Year Final Research Report
Supporting system for regenerative medicine by utilizing three-dimensional micro dynamic stimulations and active manipulations on the iPS cells
| Project/Area Number |
22360093
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dynamics/Control
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FENG Zhonggang 山形大学, 理工学研究科, 准教授 (10332545)
GOTO Kaoru 山形大学, 医学部, 教授 (30234975)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 動的刺激 / ３次元刺激 / iPS細胞 / アクティブ力学操作 / 分化誘導 / 細胞増殖 / 振動ステージ / 振動アクチュエータ |
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| Research Abstract |
We have developed completely new small sized piezoelectric three-dimensional vibration stage and a micro vibration actuator, which enable us to enforce various micro dynamic stimulations upon the cultured living iPS cells colony as well as upon a single cell. The system, not like a conventional approach but based on the principle of mechanics, has an ability to support development of the regenerative medicine. The results suggest that utilization of appropriate dynamic stimulation may be a promising approach not only to accelerate iPS cells proliferation but also to improve differentiation efficiency of iPS cells into neurons as well as neuronal networking.
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