2012 Fiscal Year Final Research Report
Molecular mechanism of homologous chromosome pairing in meiotic prophase
| Project/Area Number |
22370004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | National Institute of Information and Communications Technology |
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Principal Investigator |
DLNG Daqiao 独立行政法人情報通信研究機構, 未来1CT研究所バイオ1CT研究室, 主任研究員 (50359080)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 染色体 / 遺伝学 / 減数分裂 / RNA |
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| Research Abstract |
Pairing of homologous chromosome is an essential step in meiosis to ensure effective homologous recombination and reductional segregation in meiotic division. However, no mechanisms for chromosome specific recognition have ever been found. Here we found a meiotic-specific non-coding RNA, meiRNA-L, which forms an RNA dot on chromosome, plays an important role in recognition and pairing of homologous chromosome in early stage of meiosis.
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