2012 Fiscal Year Final Research Report
Molecular mechanisms and regulation of DGK-related physiological functions and refractory diseases
| Project/Area Number |
22370047
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Chiba University |
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Principal Investigator |
SAKANE Fumio 千葉大学, 大学院・理学研究科, 教授 (10183815)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞情報伝達機構 |
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| Research Abstract |
Diacylglycerol (DG) kinase has ten isozymes. We have recently found that DGK isozymes play pivotal roles in a wide variety of signal transduction pathways and are involved in pathogenesis of refractory diseases. Thus, we planed to reveal the mechanisms of regulation of signal transduction pathways by DGK isozymes and their novel patho-physiological functions. To this end, we first established several new analytical methods. Moreover, we obtained interesting results concerning the patho-physiological functions and the activity regulation of DGKα, γ, δ and η.
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[Journal Article] Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assaymethod2013
Author(s)
Sato, M., Liu, K., Sasaki, S., Kunii, N., Sakai, H., Mizuno, H., Saga, H. and Sakane, F.
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Journal Title
Pharmacology
Volume: (in press)
Peer Reviewed
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[Journal Article] Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras-Raf-MEK-ERK pathway2012
Author(s)
Takeishi, K., Taketomi, A., Shirabe, K., Toshima, T., Sakane, F. and Maehara, Y.
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Journal Title
J. Hepatol
Volume: 57(1)
Pages: 77-83
Peer Reviewed
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[Journal Article] c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase α by phosphorylation at Tyr2182012
Author(s)
Matsubara, T., Ikeda, M., Kiso, Y., Sakuma, M., Yoshino, K., Sakane, F., Merida, I. Saito, N. and Shirai, Y.
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Journal Title
J. Biol. Chem
Volume: 287(8)
Pages: 5507-5517
Peer Reviewed
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[Journal Article] Zinc binding drives sheet formation by the SAM domain of diacylglycerol kinase δ2010
Author(s)
Knight, M. J., Joubert, M. K., Plotkowski, M.L., Kropat, J., Gingery, M., Sakane, F., Merchant, S. S., Modlin, R. L. and Bowie, J. U.
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Journal Title
Biochemistry
Volume: 49(44)
Pages: 9667-9676
Peer Reviewed
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[Presentation] Both C1 domain and a basic amino acid cluster at C-terminus are important for branching and neurite induction of DGKβ2013
Author(s)
Shirai, Y., Kano, T., Kouzuki, T., Ueda, S., Yamanoue, M., Sakane, F. and Saito, N.
Organizer
Neuro 2013/The11th World Federation of Societies ofBiological Psychiatry: Kyoto
Year and Date
20130620-23
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[Presentation] The biological significance of diacylglycerol kinase alpha expression in hepatocellular carcinoma2010
Author(s)
武石一樹,武冨紹信,調憲,戸島剛男,本村貴志,間野洋平,伊地知秀樹,原田昇,内山秀明,吉住朋晴,坂根郁夫,前原喜彦
Organizer
第69回日本癌学会学術総会
Place of Presentation
大阪
Year and Date
20100922-24
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[Presentation] 肝細胞癌におけるジアシルグリセロールキナーゼα発現の意義2010
Author(s)
武石一樹,調憲,武冨紹信,森田和豊,戸島剛男,本村貴志,間野洋平,梅田健二,萱島寛人,二宮瑞樹,内山秀明,副島雄二,坂根郁夫,前原喜彦
Organizer
第110回日本外科学会総会
Place of Presentation
名古屋
Year and Date
20100408-10
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[Book] 生化学事典3章:脂質,朝倉書店,東京
Author(s)
坂根郁夫
Publisher
ジアシルグリセロール/トリアシルグリセロール.田中啓二,石浦章一,水島昇,谷口直之,遠藤玉夫,竹縄忠臣,伊藤俊樹,花岡文雄,塩見晴彦編
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