2012 Fiscal Year Final Research Report
Analysis of RACK function in specific nascent peptide-dependent translation arrest
| Project/Area Number |
22370062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Tohoku University |
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Principal Investigator |
INADA Toshifumi 東北大学, 大学院・薬学研究科, 教授 (40242812)
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| Co-Investigator(Renkei-kenkyūsha) |
HOSHINO Shin-ichi 名古屋市立大学, 大学院・薬学研究科, 教授 (40219168)
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| Project Period (FY) |
2010 – 2012
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| Keywords | mRNA 品質管理 / 翻訳アレスト / 新生ポリペプチド鎖 / mRNA 分子内切断 / ユ ビキチン化 / プロテアソーム / リボソーム / リボソーム解離因子 |
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| Research Abstract |
The receptor for activated C kinase (RACK1) was identified as a factor required for nascent peptide-dependent translation arrest, and the binding of RACK1 to 40S subunit is crucial for translation repression by poly-basic amino acid sequence. Two E3 ubiquitin ligases, Ltn1 and Not4, are involved in proteasomal protein degradation coupled to translation arrest, and translation arrest by RACK1 is required for Ltn1-depepdnet protein degradation.
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Research Products
(16 results)
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[Journal Article] A ribosome-bound quality control complex triggers nascent peptides and signals translation stress2012
Author(s)
Brandman, O., Ornstein, JS., Wong, D., Larson, A., Williams, C.C, Li, G.W., Zhou, S., King, D., Shen, P.S, Weibezahn, J., Dunn, J.G, Rouskin, S., Inada, T., Frost, A., Weissman, JS
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Journal Title
Cell
Volume: 151
Pages: 1042-1054
DOI
Peer Reviewed
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[Journal Article] Dom34:Hbs1 Plays a General Role in Quality Control Systems by Dissociation of Stalled Ribosome at 3' End of Aberrant mRNA2012
Author(s)
Tsuboi, T., Kuroha, K., Kudo, K., Makino S., Inoue, E., Kashima, I. and ^*Inada, T
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Journal Title
Mol. Cell
Volume: 26
Pages: 518-529
DOI
Peer Reviewed
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[Journal Article] RACK1 stimulates nascent polypeptide-dependent translation arrest2010
Author(s)
Kuroha, K., Akamatsu, M., Dimitrova, L., Ito, T., Kato, Y. Shirahige, K. and ^*Inada, T
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Journal Title
EMBO Rep
Volume: 11
Pages: 956-961
DOI
Peer Reviewed
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