2012 Fiscal Year Final Research Report
Regulatory network controlling mammalian Golgi stress response by bHLH-ZIP transcription factors
| Project/Area Number |
22370069
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | University of Hyogo |
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Principal Investigator |
YOSHIDA Hiderou 兵庫県立大学, 大学院・生命理学研究科, 教授 (60378528)
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| Co-Investigator(Renkei-kenkyūsha) |
WAKABAYASHI Sadao 兵庫県立大学, 大学院・生命理学研究科, 准教授 (80148436)
TANIGUCHI Mai 兵庫県立大学, 大学院・生命理学研究科, 助教 (00423898)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞構造・機能 / ゴルジ体 |
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| Research Abstract |
The Golgi stress response is an autoregulatory mechanism that controls the capacity of the Golgi apparatus in accordance with cellular demands. The applicant is trying to reveal the molecular mechanism of the Golgi stress response as a pioneer. By preliminary experiments I isolated a key transcription factor TFE3 that regulates the mammalian Golgi stress response. In this project, I revealed that activity of TFE3 is regulated by its subcellular localization, which is controlled through phosphorylation status of TFE3. In addition, I found that deficiency of glycosylation as well as vesicular transport in the Golgi apparatus is responsible for activation of the Golgi stress response. Moreover, the TFE3 pathway is activated during differentiation of neurons, glial cells and goblet cells, suggesting the biological significance of the Golgi stress response.
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[Presentation]2012
Author(s)
Hiderou Yoshida
Organizer
EMBO-EMBL Symposium
Year and Date
20120000
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[Presentation]2012
Author(s)
Soichiro Tanakura他
Organizer
第85回日本生化学会大会
Year and Date
20120000
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[Presentation]2011
Author(s)
Hiderou Yoshida
Organizer
奈良先端未来開拓コロキウム」シンポジウム
Year and Date
20110000
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