2012 Fiscal Year Final Research Report
Regulation of mitochondrial dynamics in mammals
| Project/Area Number |
22370071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIHARA Hidenori 九州大学, 医学研究院, 助教 (40380612)
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| Co-Investigator(Renkei-kenkyūsha) |
ISIHARA Naotada 久留米大学, 分子生命科学研究所, 教授 (10325516)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞構造・機能 / ミトコンドリアダイナミクス |
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| Research Abstract |
(1) Generation and phenotype analysis of whole body and neuron-specific Drp1-KO mice.Tissue-specific Drp1-KO mice including liver, oocyte. heart muscle, and pancreatic beta-cell have been generated and their phenotypes are now under investigation.
(2) Identification of Mff of mitochondrial outer membrane (MOM) as the major Drp1 receptor.
(3) Identification of a new KIF family protein KLP6 functioning as an axonal mitochondria transport motor.
(4) Identified a Rab-GAP protein TBC1D15 as the ligand of MOM hFis1 protein involved in mitochondrial morphology regulation.
(5) Demonstration that Drp1 depletion or inhibition of its function increases mitochondrial nucleoid size concomitant with the mitochondrial network extension and formation of tightly packed cristae structure as a response to prevent cells from apoptotic death.
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[Journal Article] Fis1 acts as mitochondrial recruitment factor for TBC1D15 that involved in regulation of mitochondrial morphology.2012
Author(s)
K. Onoue, A. Jofuku, R. Ban-Ishihara, T. Ishihara, M. Maeda, T. Koshiba, T. Itoh, M. Fukuda, H. Otera, T. Oka, H. Takano, N. Mizushima, K. Mihara and N. Ishihara
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Journal Title
J. Cell Sc
Volume: 126
Pages: 176-185
Peer Reviewed
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[Journal Article] PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria2012
Author(s)
K. Okatsu, T. Oka, M. Iguchi, K. Imamura, H. Kosako, N. Tani, M. Kimura, E. Go, F. Koyano, M. Funayama, K. Shiba-Fukushima, S. Sato, H. Shimizu, Y. Fukunaga, H. Taniguchi, M. Kamatsu, N. Hattori, K. Mihara, K. Tanaka, and N. Matsuda
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Journal Title
Nature Communications
Volume: 1016
Pages: 1-10
DOI
Peer Reviewed
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