2012 Fiscal Year Final Research Report
Integrin dependent cellular growth and functions through the mammalianhippo pathway
| Project/Area Number |
22370072
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | Mst1,Mst2,インテグリン / Outside-in シグナル / Rap1 |
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| Research Abstract |
Mst1/Mst2, Mammalian homolog of Hippo associates with Rap1 effector RAPL and regulates lymphocyte adhesion and migration through leukocyte integrin LFA-1. Furthermore, RAPL negatively regulate cell cycle through G1 cyclin inhibitor p27Kip1. In addition, tissue imaging analysis has revealed that Mst1 is required for efficient thymocyte trafficking and selection. Consequently, deficiencies of RAPL and Mst1 lead to lymphoproliferative and autoimmune-like disorders.
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Research Products
(13 results)
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[Journal Article] DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.2012
Author(s)
Harada Y., Tanaka Y., Terasawa M., Pieczyk M., Habiro K., Katakai T., Hanawa-Suetsugu K., Kukimoto-Niino M., Nishizaki T., Shirouzu M., Duan X., Uruno T., Nishikimi A., Sanematsu F., Yokoyama S., Stein J.V., Kinashi T., and Fukui Y..
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Journal Title
Blood.
Volume: 119
Pages: 4451-61
DOI
Peer Reviewed
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[Journal Article] RAPL deficiency causedlymphoproliferative disordersthrough the mislocalization of p27kip.2011
Author(s)
Katagiri, K., Ueda, Y., Tomiyama, T., Yasuda, K., Toda, Y., Ikehara, S., Nakayama, K.I, Kinashi, T.
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Journal Title
Immunity.
Volume: 34
Pages: 1-15
DOI
Peer Reviewed
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