2014 Fiscal Year Final Research Report
Molecular mechanisms underlying the sorting of bacterial lipoproteins.
| Project/Area Number |
22380049
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Morioka College |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | Lolシステム / リポ蛋白質 / 膜局在化 / ペリプラズム / 分子シャペロン / 細胞表層構造 / ABCトランスポーター / 阻害剤 |
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| Outline of Final Research Achievements |
The Lol system catalyzing the sorting of lipoproteins from the inner to outer membranes was studied and the following five major findings were obtained. (1) LolC and LolD are functionally different to each other although their structures are similar. (2) Detailed molecular events involving lipoproteins, LolCDE, LolA, and LolB were revealed. (3) Defective lipoprotein sorting induces the Rcs stress response system. (4) The site of LolB required for membrane targeting was identified. (5) Chemicals, which inhibit the function of LolC and LolE, were found.
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| Free Research Field |
生化学
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