2012 Fiscal Year Final Research Report
Molecular mechanism of inflammatory cytokine signaling and its regulation by bioprobes
| Project/Area Number |
22380060
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
KATAOKA Takao 京都工芸繊維大学, 工芸科学研究科, 准教授 (20242307)
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| Project Period (FY) |
2010 – 2012
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| Keywords | シグナル伝達 / 生理活性 / 炎症性サイトカイン / NF-κB / トリエン-アンサマイシン / トリコテセン / オイデスマン |
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| Research Abstract |
Inflammatory cytokines, such as tumor necrosis factor-α and interleukin-1, induce the activation of the transcription factor nuclear factor κB (NF-κB) signaling pathway, and regulate diverse cellular functions through its gene expression. Inflammatory cytokines are shown to be involved in autoimmune diseases, cancer, and diabetes. In this study, mechanisms of actions of bioactive small compounds (bioprobes) on the NF-κB signaling pathway and gene expression induced by inflammatory cytokines were elucidated.
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