• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Total synthesis and structure activity relationship of natural products with potent anticancer activity and unique structures

Research Project

  • PDF
Project/Area Number 22380064
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioproduction chemistry/Bioorganic chemistry
Research InstitutionTohoku University

Principal Investigator

KUWAHARA Shigefumi  東北大学, 大学院・農学研究科, 教授 (30170145)

Co-Investigator(Kenkyū-buntansha) KIYOTA Hiromasa  東北大学, 大学院・農学研究科, 准教授 (30234397)
Co-Investigator(Renkei-kenkyūsha) IGARASHI Yasuhiro  富山県立大学, 工学部, 教授 (20285159)
Project Period (FY) 2010 – 2012
Keywords有機化学 / 有機合成化学 / 全合成 / cytotoxic / antitumor / lactimidomycin / oxylipin
Research Abstract

Total syntheses of natural products with unique structural architectures as well as potent cytotoxicity and/or migration inhibitory activity against several cancer cell lines have been accomplished. Most of the syntheses were the fist examples of the total synthesis of the targeted molecules. Structure activity relationship study on lupinacidins, potent cancer cell migration inhibitors, led to the discovery of an analog which was comparable to lupinaidin C (most potent migration inhibitor among the three congeners) in activity.

  • Research Products

    (11 results)

All 2013 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Synthesis of rumphellaone A via epoxy nitrile cyclization2012

    • Author(s)
      Takafumi Hirokawa, Shigefumi Kuwahara
    • Journal Title

      Tetrahedron

      Volume: vol. 68 Pages: 4581-4587

    • DOI

      DOI:10.1016/j.tet.2012.04.035

    • Peer Reviewed
  • [Journal Article] Enantioselective synthesis of rumphellaone A via epoxy nitrile cyclization2012

    • Author(s)
      Takafumi Hirokawa, Tomohiro Nagasawa, Shigefumi Kuwahara
    • Journal Title

      Tetrahedron Lett

      Volume: vol. 53 Pages: 705-706

    • DOI

      doi:10.1016/j.tetlet.2011.11.145

    • Peer Reviewed
  • [Journal Article] Synthesis of aspergillide A via proline-catalyzed trans-to-cis isomerization of a substituted tetrahydropyran2011

    • Author(s)
      Tomohiro Nagasawa, Tomoo Nukada, Shigefumi Kuwahara
    • Journal Title

      Tetrahedron

      Volume: vol. 67 Pages: 2882-2888

    • DOI

      DOI:10.1016/j.tet.2011.02.061

    • Peer Reviewed
  • [Journal Article] Stereoselective synthesis of malyngic acid and fulgidic acid2011

    • Author(s)
      Yusuke Kurashina, Ayako Miura, Masaru Enomoto, Shigefumi Kuwahara
    • Journal Title

      Tetrahedron

      Volume: vol. 67 Pages: 1649-1653

    • DOI

      DOI:10.1016/j.tet.2011.01.005

    • Peer Reviewed
  • [Journal Article] Synthesis of lupinacidins A and B via sequential cycloaddition.double elimination2010

    • Author(s)
      Kohei Sugimoto, Masaru Enomoto,Shigefumi Kuwahara
    • Journal Title

      Tetrahedron Lett

      Volume: vol. 51 Pages: 4570-4572

    • DOI

      doi:10.1016/j.tetlet.2010.06.121

    • Peer Reviewed
  • [Presentation] Pestaloquinol A,BおよびCytosporin Dの全合成研究2013

    • Author(s)
      廣川高史,山真将,桑原重文
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内キャンパス
    • Year and Date
      2013-03-25
  • [Presentation] 癌細胞浸潤阻害物質BU-466Lの合成研究2013

    • Author(s)
      藤田聡美,渡邊麻衣,廣川高史,榎本賢,桑原重文
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内キャンパス
    • Year and Date
      2013-03-25
  • [Presentation] Lactimidomycinの全合成研究2011

    • Author(s)
      永沢友裕,桑原重文
    • Organizer
      第53回天然有機化合物討論会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2011-09-28
  • [Presentation] 特異な環構造を有する生物活性天然物の全合成2010

    • Author(s)
      桑原重文
    • Organizer
      第54回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      山梨大学甲府キャンパス
    • Year and Date
      2010-10-24
  • [Presentation] 特異な環構造を有する生物活性天然物の合成研究2010

    • Author(s)
      桑原重文
    • Organizer
      平成22年度化学系学協会東北大会
    • Place of Presentation
      岩手大学工学部
    • Year and Date
      2010-09-25
  • [Remarks]

    • URL

      http://www.agri.tohoku.ac.jp/yuuki/index-j.html

URL: 

Published: 2014-08-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi