Development and the innovative application of novel functional molecules based on sialo-glycans

2014 Fiscal Year Final Research Report

• Project/Area Number: 22380067
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bioproduction chemistry/Bioorganic chemistry
• Research Institution: Gifu University
• Principal Investigator: KISO MAKOTO 岐阜大学, 応用生物科学部, 特任教授 (90092931)
• Co-Investigator(Kenkyū-buntansha): HIDEHARU Ishida 岐阜大学, 応用生物科学部, 教授 (20203002)
• Co-Investigator(Renkei-kenkyūsha): TAKESHI Tsubata 東京医科歯科大学, 疾患生命科学研究部, 教授 (80197756)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: シアル酸 / 糖鎖 / ガングリオシド / DDS / ウィルス感染 / マイコプラズマ / CD22 / 創薬

Outline of Final Research Achievements

Sialic acid-linked glycan chains (sialoglycans) are located on cell surface as the components of glycolipid gangliosides and glycoproteins, serving the receptor functions for microbial toxins and viral infections. They are also related to cell adhesion, cell-cell communication, immune response, cell growth and differentiation, oncogenesis, inflammation, and neural disorders, etc. In this research project, based on the development of practical chemical synthesis and construction of the library of sialoglycan complexes, as well as on the structure-activity relationship study, development of the glycan-driven drug delivery system (glycan DDS) and the single-molecule imaging of membrane functions by the newly synthesized fluorescent gangliosides were achieved. The glycan roles on the stem cell surface were studied by novel technology.

Free Research Field

糖鎖工学、ケミカルバイオロジー