Evaluatuion ofstress-inducedactivation of quercetinand its multifunctional dynamics

2012 Fiscal Year Final Research Report

• Project/Area Number: 22380077
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: The University of Tokushima
• Principal Investigator: TERAO Junji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60093275)
• Co-Investigator(Kenkyū-buntansha): KAWAI Yoshichika 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (50380027) ; MUKAI Rie 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (90547978)
• Project Period (FY): 2010 – 2012
• Keywords: 食品 / ストレス / 発現制御 / 分析化学 / シグナル伝達、筋萎縮 / β-βグルクロニダーゼ / 炎症

Research Abstract

This study was aimed to evaluate the multifunctional mechanism of quercetin as a antioxidative ingredient derived from plant foods. Rodent experiments demonstrated that dietary quercetin protects the intestinal mucosa of digestive tract, blood vessel, central nervous system and muscle tissue from oxidative stress by promoting the antioxidant enzyme expression as well asdirect ROS-scavenging and suppression of oxidant enzymes. It is implied that de-conjugation reaction by macrophage participates in these multifunction of dietary quercetin.

Research Products

• [Journal Article] Plasma HDL reduces nonesterified fatty acid hydroperoxides originating from oxidized LDL: a mechanism for its antioxidant ability (2013)
  • Author(s): Kotosai M., Shimada S., Kanda M., Matsuda N., Sekido K., Shimizu Y., Tokumura A.,Nakamura T., Murota K., Kawai Y., TeraoJ.
  • Journal Title: Lipids Volume: 48 Pages: 569-578.
  • DOI: doi:10.1007/s11745-013-3779-1
  • Peer Reviewed
• [Journal Article] Evaluation of theinhibitory effects of quercetin-related flavonoids and catechins on themonoamine oxide-se-A reaction in mouse brain mitochondria Journal of Agricultural (2012)
  • Author(s): Bandaruk Y., Mukai R., Kawamura T., Nemoto H Terao J.
  • Journal Title: Food Chemistry Volume: 60 Pages: 10270-10277
  • DOI: doi10.1021/jf303055b
  • Peer Reviewed
• [Journal Article] Prevention of disusemuscle atrophy by dietary ingestion of 8-prenylnaringenin in denervated mice (2012)
  • Author(s): Mukai R., Horikawa H., Fujikura Y., Kawamura T., Nemoto H., Nikawa T.
  • Journal Title: PLoS ONE Volume: 9 Pages: e45048
  • DOI: doi:10.1371/journal.pone.0045048
  • Peer Reviewed
• [Journal Article] Effect of quercetin and its glucuronide metabolites upon 6-hydroxydopamineinduced oxidative damage in neuro-2a cells (2012)
  • Author(s): Mukai R., Kawabata K., Otsuka S., Ishisaka A., Kawai Y., Ji Z-S., Tsuboi H., Terao J.
  • Journal Title: Free Radi-cal Research Volume: 8 Pages: 1019-1028
  • DOI: doi:10.3109/10715762.2012.763720
  • Peer Reviewed
• [Journal Article] Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats (2011)
  • Author(s): Ishisaka A, IchikawaS., Sakakibara H., Piskula M., Nakamura T., Kato Y., Ito M.,Miyamoto K., Tsuji A., Kawai Y., Terao J.
  • Journal Title: ree Radicals Biology and Medicine Volume: 51 Pages: 1329-1336
  • DOI: doi:10.1016/j.freeradbiomed.2011.06.017
  • Peer Reviewed
• [Journal Article] Effect of quercetin and glucuroni-de metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria. (2011)
  • Author(s): S. Yoshino, Hara A, Sakakibara H, Kawabata K, Tokumura A, Ishisaka A, Kawai Y, Terao J
  • Journal Title: Nutrition Volume: 27 Pages: 7-8
  • DOI: doi:10.1016/j.nut.2010.09.002
  • Peer Reviewed
• [Journal Article] Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo (2011)
  • Author(s): Terao J. Murota K, Kawai Y
  • Journal Title: Food and Function Volume: 2 Pages: 11-17
  • DOI: doi:10.1039/c0fo00106f
  • Peer Reviewed
• [Book] Bioavailability of Flavonols and Flavones (2012)
  • Author(s): PIskula MK., Murota K., Terao J.
  • Total Pages: 93-107
  • Publisher: CRC
• [Book] lavonoid and related compounds (Chapter 4. Bioavailability of Flavonols and Falvones (2012)
  • Author(s): M. Piskula, K. Murota, J. Terao
  • Total Pages: 173-186
  • Publisher: CRC
• [Book] フラボノイド (Functional Food第19号)
  • Author(s): 寺尾純二
  • Publisher: フジメディカル