2012 Fiscal Year Final Research Report
Evaluatuion ofstress-inducedactivation of quercetinand its multifunctional dynamics
| Project/Area Number |
22380077
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TERAO Junji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60093275)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Yoshichika 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (50380027)
MUKAI Rie 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (90547978)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 食品 / ストレス / 発現制御 / 分析化学 / シグナル伝達、筋萎縮 / β-βグルクロニダーゼ / 炎症 |
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| Research Abstract |
This study was aimed to evaluate the multifunctional mechanism of quercetin as a antioxidative ingredient derived from plant foods. Rodent experiments demonstrated that dietary quercetin protects the intestinal mucosa of digestive tract, blood vessel, central nervous system and muscle tissue from oxidative stress by promoting the antioxidant enzyme expression as well asdirect ROS-scavenging and suppression of oxidant enzymes. It is implied that de-conjugation reaction by macrophage participates in these multifunction of dietary quercetin.
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[Journal Article] Plasma HDL reduces nonesterified fatty acid hydroperoxides originating from oxidized LDL: a mechanism for its antioxidant ability2013
Author(s)
Kotosai M., Shimada S., Kanda M., Matsuda N., Sekido K., Shimizu Y., Tokumura A.,Nakamura T., Murota K., Kawai Y., TeraoJ.
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Journal Title
Lipids
Volume: 48
Pages: 569-578.
DOI
Peer Reviewed
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[Journal Article] Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats2011
Author(s)
Ishisaka A, IchikawaS., Sakakibara H., Piskula M., Nakamura T., Kato Y., Ito M.,Miyamoto K., Tsuji A., Kawai Y., Terao J.
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Journal Title
ree Radicals Biology and Medicine
Volume: 51
Pages: 1329-1336
DOI
Peer Reviewed
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