2013 Fiscal Year Final Research Report
Developmental control system of asymmetry of eye-sidedness and body coloration in flatfishes, and the mechanism that induces abnormality in the asymmetry development
| Project/Area Number |
22380104
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General fisheries
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI Tohru 東北大学, (連合)農学研究科(研究院), 教授 (70344330)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOI Hayato 東北大学, 大学院・農学研究, 助教 (40569729)
UJI Susumu 独立行政法人水産総合研究センター, 増養殖研究所, 研究員 (40372049)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJINAMI Yuichiro 独立行政法人水産総合研究センター, 東北区水産研究所, 技術開発員 (30443360)
SHIMIZU Daisuke 独立行政法人水産総合研究センター, 東北区水産研究所, 技術開発員 (40443361)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | ヒラメ･カレイ / 異体類 / 左右非対称性 / Nodal経路 / 色素胞分化 / 変態 / 脊椎骨発生 / 種苗生産 |
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| Research Abstract |
We investigated the developmental mechanism that controls external asymmetry of flatfish (eye location and skin pigmentation). It was demonstrated that the Nodal signaling pathway (NSP), which is known to control the sidedness of internal organs and neural circuit of habenulae, fixes the eye-sidedness by controlling the forebrain asymmetry formation. The dextral and sinistral flatfishes are segregated by the opposite asymmetry formation at the habenulae and optic chiasma under the control of the NSP.
It was found that the precursors of adult-type melanophores that locate at the base of dorsal fin migrate in the myoseptum toward both left and right lateral sides. The asymmetry of skin pigmentation is established by the maturation of precursors to chromatoblasts during the migration in the myoseptum of the ocular side. Exposure to retinoic acid (RA) induces maturation of the precursors also in the ocular side, resulting in the coloration of blind side skin.
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[Journal Article] Threemembers of iodothyronine deiodinase family, dio1, dio2 and dio3, are expressed in spatially and temporally specificmanners during flounder, Paralichthys olivaceus,metamorphosis2010
Author(s)
伊藤香絵, 渡辺耕平, 鷲尾洋平, 烏暁明, 有瀧真人, 鈴木徹
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Journal Title
Zoological Science
Volume: 27巻
Pages: 574-580
DOI
Peer Reviewed
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[Remarks] 新聞報道:2013年10月28日 朝日新聞朝刊「右利き左利きの謎に迫る」
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[Remarks] 科研費NEWS: 科研費からの展開事例「ヒラメやカレイの目の偏りが生じるメカニズムを解明」2011, 3巻, 21ページ
