2012 Fiscal Year Final Research Report
Modulation and optimization of immune response utilizing complement regulatory factors in fish
| Project/Area Number |
22380111
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General fisheries
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKAO Miki 九州大学, 大学院・農学研究院, 教授 (50212080)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 魚類 / 免疫 / 生体防御 / 補体 |
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| Research Abstract |
In order to elucidate molecular mechanism of complement regulatory factors, Tecrem and properdin (Pf), in modulating immune responses in fish, gene diversity, functional analysis at both mRNA and protein levels of zebrafish, carp, and ginbuna crucian carp Tecrem were conducted. We succeeded to prepare of recombinant carp Tecrem and to establish monoclonal antibody to carp Tecrem, and elucidated its wide tissue and cellular distribution, expression response to viral infection, suggesting key role of Tecrem in host immune system
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