2013 Fiscal Year Final Research Report
Creation of judging method for livestock egg quality based on the molecular mechanism of follicular selection
| Project/Area Number |
22380148
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MANABE Noboru 東京大学, 農学生命科学研究科, 教授 (80243070)
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| Co-Investigator(Kenkyū-buntansha) |
MIYANO Takashi 神戸大学, 大学院・農学研究科, 教授 (80200195)
OKUDA Kiyoshi 岡山大学, 大学院・自然科学研究科, 教授 (40177168)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 卵子品質 / 卵胞閉鎖 / 細胞死阻害因子 / 顆粒層細胞 / アポトーシス / 家畜卵巣 / 発現制御 |
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| Research Abstract |
Less than 1% of several hundreds of thousand primordial follicles in livestock ovary leads to ovulation, and the rest to selectively disappear by atresia. Many studies in endocrine have been performed but follicle selection mechanism is unknown. We have shown that intracellular signaling pathway of cell death ligand-receptor system that regulates follicle granulosa cell apoptosis is the key to control the follicle selection. In the present project, the factors in this signaling pathway were precisely examined. We indicated that the signal inhibitors are involved in dominant factor to control the follicle selection, and that they are useful as an indicator of oocyte quality determination.
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