• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Creation of judging method for livestock egg quality based on the molecular mechanism of follicular selection

Research Project

  • PDF
Project/Area Number 22380148
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied animal science
Research InstitutionThe University of Tokyo

Principal Investigator

MANABE Noboru  東京大学, 農学生命科学研究科, 教授 (80243070)

Co-Investigator(Kenkyū-buntansha) MIYANO Takashi  神戸大学, 大学院・農学研究科, 教授 (80200195)
OKUDA Kiyoshi  岡山大学, 大学院・自然科学研究科, 教授 (40177168)
Project Period (FY) 2010-04-01 – 2014-03-31
Keywords卵子品質 / 卵胞閉鎖 / 細胞死阻害因子 / 顆粒層細胞 / アポトーシス / 家畜卵巣 / 発現制御
Research Abstract

Less than 1% of several hundreds of thousand primordial follicles in livestock ovary leads to ovulation, and the rest to selectively disappear by atresia. Many studies in endocrine have been performed but follicle selection mechanism is unknown. We have shown that intracellular signaling pathway of cell death ligand-receptor system that regulates follicle granulosa cell apoptosis is the key to control the follicle selection. In the present project, the factors in this signaling pathway were precisely examined. We indicated that the signal inhibitors are involved in dominant factor to control the follicle selection, and that they are useful as an indicator of oocyte quality determination.

  • Research Products

    (17 results)

All 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (5 results) (of which Invited: 4 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Supplementation of culture medium with L-carnitine improves development and cryotolerance of bovine embryos produced in vitro2013

    • Author(s)
      Takahashi T (7名)
    • Journal Title

      Reprod. Fertil. Dev.

      Volume: 25 Pages: 589-599

    • Peer Reviewed
  • [Journal Article] Fertilization ability of porcine oocytes reconstructed from ooplasmic fragments produced and characterized after serial centrifugations2013

    • Author(s)
      Linh N
    • Journal Title

      J. Reprod. Dev.

      Volume: 59 Pages: 549-556

    • DOI

      10.1262/jrd.2013-042

    • Peer Reviewed
  • [Journal Article] Luteoprotective roles of luteinizing hormone are mediated by not only progesterone production but also glucocorticoid conversion in bovine corpus luteum2013

    • Author(s)
      Kawaguchi S
    • Journal Title

      Mol. Reprod. Dev.

      Volume: 80 Pages: 204-215

    • DOI

      10.1002/mrd.22150

    • Peer Reviewed
  • [Journal Article] Summer heat stress affects prostaglandin synthesis in the bovine oviduct2013

    • Author(s)
      Kobayashi Y
    • Journal Title

      Reproduction

      Volume: 146 Pages: 103-110

    • DOI

      10.1530/REP-12-0479

    • Peer Reviewed
  • [Journal Article] Effect of androstenedione on the growth and meiotic competence of bovine oocytes from early antral follicles2012

    • Author(s)
      Taketsuru H
    • Journal Title

      Zygote

      Volume: 20 Pages: 407-415

    • DOI

      10.1017/S0967199411000268

    • Peer Reviewed
  • [Journal Article] In vivo imaging of hierarchical spatiotemporal activation of caspase-8 during apoptosis2012

    • Author(s)
      Kominami K
    • Journal Title

      PLoS ONE

      Volume: 7 (11) Pages: e50218

    • DOI

      10.1371/journal.pone.0050218

    • Peer Reviewed
  • [Journal Article] The molecular mechanism of apoptosis upon caspase-8 activation : quantitative experimental validation of a mathematical model2012

    • Author(s)
      Kominami K
    • Journal Title

      Biochim. Biophys. Acta (Mol. Cell Res.)

      Volume: 1823 Pages: 1825-1840

    • Peer Reviewed
  • [Presentation] Cutting edge of bovine reproductive technology2014

    • Author(s)
      Manabe N
    • Organizer
      The 2nd Symposium of the Thai Society for Animal Reproduction
    • Place of Presentation
      Bngkok, Thailand
    • Year and Date
      20140320-21
    • Invited
  • [Presentation] High expression of Bid in follicular granulosa cells is characteristics in Mangalica ovaries2013

    • Author(s)
      Manabe N
    • Organizer
      The 2nd International Conference of Fatty Pigs
    • Place of Presentation
      Herceghalom, Hungary
    • Year and Date
      20131122-24
  • [Presentation] Production of prion gene homo-knockout caws to prevent spontaneous bovine spongiform encephalopathy and their characteristics2013

    • Author(s)
      Manabe N
    • Organizer
      The 46th Annual Meeting of Society of Physiology and Pathology of Reproduction
    • Place of Presentation
      Gdańsk, Poland
    • Year and Date
      20130227-0301
    • Invited
  • [Presentation] Roles of decoy receptor 3 in physiological programmed cell death in ovarian follicular granulosa cells2012

    • Author(s)
      Manabe N
    • Organizer
      The 15th Asian Animal Science Congress
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      20121126-27
    • Invited
  • [Presentation] Bcl-2 members, Bid and Bax, are involved in granulosa cell apoptosis in saws2012

    • Author(s)
      Manabe N
    • Organizer
      The 17th International Congress on Animal Reproduction
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      20120729-0802
    • Invited
  • [Book] 生殖細胞と生殖器, 「繁殖生物学」(日本繁殖生物学会編)2013

    • Author(s)
      眞鍋昇. インターズー
    • Total Pages
      18-39/313
  • [Book] Abnormalities of ovarian and testicular function in senescence accelerated mice, 「The Senescence-Accelerated Mouse」(Takeda T eds.)2013

    • Author(s)
      Manabe N
    • Total Pages
      273-286/580
    • Publisher
      Elsevier Science Publishers
  • [Book] 顆粒層細胞アポトーシスの分子機構, 「卵子学」2011

    • Author(s)
      眞鍋昇
    • Total Pages
      424-432/1,195
    • Publisher
      京都大学出版会
  • [Book] 卵子(卵胞)形成と雌の性周期, 「新動物生殖学」2011

    • Author(s)
      宮野隆
    • Total Pages
      84-94/203
    • Publisher
      朝倉書店
  • [Remarks]

    • URL

      http://park.itc.u-tokyo.ac.jp/bokujo/

URL: 

Published: 2015-06-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi