2013 Fiscal Year Final Research Report
Molecular mechanism of anti-parasite response of midgut bacteria of vector insect
| Project/Area Number |
22380155
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
FUKUMOTO Shinya 帯広畜産大学, 原虫病研究センター, 准教授 (50376422)
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| Co-Investigator(Kenkyū-buntansha) |
KANUKA Hirotaka 慈恵会医科大学, 医学部, 教授 (50342770)
KOIKE Masanori 帯広畜産大学, 畜産学部, 教授 (00205303)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | マラリア / 腸内細菌 / ハマダラカ |
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| Research Abstract |
To investigate the response mechanisms within the midgut environment, including those influenced by resident microbiota against malaria parasite, we focus on a midgut bacteria species intra-specific variation that confers diversity to the mosquito`s competency for malaria parasite transmission. Serratia marcescens isolated from laboratory-reared mosquitoes shows great phenotypic variation in its cellular and structural features. This variation is directly correlated with its ability to inhibit Plasmodium parasite development within the mosquito midgut. These findings indicated that strategies for controlling malaria through genetic manipulation of midgut bacteria within the mosquito.
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[Journal Article] Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii2013
Author(s)
Saiki, E., Nagao, K., Aonuma, H., Fukumoto, S., Xuan, X., Bannai, M.Kanuka, H
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Journal Title
Malar J
Volume: 12
Pages: 19
Peer Reviewed
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[Journal Article] Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila2013
Author(s)
Nelson, B., Freisinger, T., Ishii, K., Okado, K., Shinzawa, N., Fukumoto, S.Kanuka, H
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Journal Title
Biochem Biophys Res Commun
Volume: 430
Pages: 1120-5
Peer Reviewed
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[Journal Article] Intra-specific diversity of Serratia marcescens in Anopheles mosquito midgut defines Plasmodium transmission capacity2013
Author(s)
Bando, H., Okado, K., Guelbeogo, W. M., Badolo, A., Aonuma, H., Nelson, B., Fukumoto, S., Xuan, X., Sagnon, N.Kanuka, H
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Journal Title
Sci Rep
Volume: 3
Pages: 1641
Peer Reviewed
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[Journal Article] In vitro and in vivo antimalarial activities of T-2307, a novel arylamidine2012
Author(s)
Kimura, A., Nishikawa, H., Nomura, N., Mitsuyama, J., Fukumoto, S., Inoue, N.Kawazu, S
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Journal Title
Antimicrob Agents Chemother
Volume: 56
Pages: 2191-3
Peer Reviewed
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[Journal Article] Development of an allele-specific, loop-mediated, isothermal amplification method (AS-LAMP) to detect the L1014F kdr-w mutation in Anopheles gambiae s. l2012
Author(s)
Badolo, A., Okado, K., Guelbeogo, W. M., Aonuma, H., Bando, H., Fukumoto, S., Sagnon, N.Kanuka, H
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Journal Title
Malar J
Volume: 11
Pages: 227
Peer Reviewed
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[Journal Article] The role of proboscis of the malaria vector mosquito Anopheles stephensi in host-seeking behavior2011
Author(s)
Maekawa, E., Aonuma, H., Nelson, B., Yoshimura, A., Tokunaga, F., Fukumoto, S.Kanuka, H
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Journal Title
Parasit Vectors
Volume: 4
Pages: 10
Peer Reviewed
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[Journal Article] A single fluorescence-based LAMP reaction for identifying multiple parasites in mosquitoes2010
Author(s)
Aonuma, H., Yoshimura, A., Kobayashi, T., Okado, K., Badolo, A., Nelson, B., Kanuka, H. Fukumoto, S
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Journal Title
Exp Parasitol
Volume: 125
Pages: 179-83
Peer Reviewed
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