2012 Fiscal Year Final Research Report
Generation of transgenic mice expressing soluble forms of Siglecs as a model for influenza-resistant pigs
| Project/Area Number |
22380161
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kyushu University |
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Principal Investigator |
ONO Etsuro 九州大学, 医学研究院, 教授 (00160903)
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| Co-Investigator(Renkei-kenkyūsha) |
TOMIOKA Yukiko 北海道大学, 遺伝子病制御研究所, 助教 (50374674)
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| Project Period (FY) |
2010 – 2012
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| Keywords | インフルエンザ / トランスジェニックマウス / ウイルス / 抗病性動物 / Siglec / 感染症 |
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| Research Abstract |
To confer the antiviral potential against influenza virus to pigs as a mixing vessel for creating a “new” influenza virus, we investigated the ability of Siglecs to inhibit influenza virus infection in vitro and in vivo by using Madin-Derby canine kidney (MDCK) cells and transgenic mice expressing a soluble form of human Siglec molecules. The transformed MDCK cells showed a significant resistance, but not the transgenic mice
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Research Products
(2 results)
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[Presentation] Antiviral effects of anti-PB2 monoclonal intrabody inhibiting the viral RNA transcription on influenza virus infections2012
Author(s)
Yoshikazu Fujimoto, Kinuyo Ozaki, Hiroki Takakuwa, Hiroshi Ito, Tatsufumi Usui, Hiroichi Ozaki, Toshiyuki Murase, Tsuyoshi Yamaguchi, Koichi Otsuki, Toshihiro Ito, Hiroshi Kida and Etsuro Ono
Organizer
9th International Congress of Veterinary Virology
Place of Presentation
Madrid, Spain
Year and Date
2012-09-04
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