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2012 Fiscal Year Final Research Report

Study on pathogenesis and transmission of animal AA amyloidosisandtheir enhancing factors

Research Project

  • PDF
Project/Area Number 22380165
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionGifu University

Principal Investigator

ISHIGURO Naotaka  岐阜大学, 応用生物科学部, 教授 (00109521)

Co-Investigator(Kenkyū-buntansha) INOSHIMA Yasuo  岐阜大学, 応用生物科学部, 准教授 (20355184)
Co-Investigator(Renkei-kenkyūsha) MATSUI Takane  帯広畜産大学, 畜産学部, 教授 (40111116)
Project Period (FY) 2010 – 2012
Keywords疾病予防 / 制御
Research Abstract

Amyloid A (AA) amyloidosis is induced in animals with high plasma concentration of precursor serum amyloid protein A (SAA), and characterized by the extracellular deposition of AA proteins in different organs and tissues. AA amyloidosis is observed by mainly in cows and table birds. In this study,several tissues from AA amyloidosis affected cows and chickens were histologically examined, and the transmission mechanism of AA amyloidosis was analyzed using chicken and rabbit models. Bovine AA amyloidosis was classified by two types Class I of typical and Class II of atypical amyloidosis by amyloid deposition and clinical symptoms. BovineAA amyloid developed experimental AA amyloidosis in rabbits. We observed fatal outbreaks of AA amyloidosis in white hens inoculated by vaccine. Chicken AA amyloidosis was shown to be transmitted within same species inoculated with vaccine and chicken amyloid.

  • Research Products

    (11 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Experimental induction and oral taransmission of avian AA amyloidosis in vaccinated white hens2013

    • Author(s)
      Tomoaki Murakami, Naeem Muhammad, Yasuo Inoshima, Tokuma Yanai, Masanobu Goryo and Naotaka Ishiguro
    • Journal Title

      Amyloid

    • DOI

      DOI:10.3109/13506129.2013.783474

    • Peer Reviewed
  • [Journal Article] AA amyloidosis in vaccinated growing chickens.2013

    • Author(s)
      Tomoaki Murakami, Yasuo Inoshima, Eiichi Sakamoto, Hideto Fukushi, Hiroki Sakai, Tokuma Yanai and Naotaka Ishiguro
    • Journal Title

      J. Comp. Pathol.

    • DOI

      DOI:10.1016/j.jcpa. 2013.02.002

    • Peer Reviewed
  • [Journal Article] Atypical AA amyloid deposits in bovine AA amyloidosis.2012

    • Author(s)
      Tomoaki Murakami, Yasuo Inoshima, Yoshiyasu Kobayashi, Takane Matusi, Hisashi Inokuma and Naotaka Ishiguro
    • Journal Title

      Amyloid

      Volume: 19 Pages: 15-20

    • Peer Reviewed
  • [Journal Article] Pathogenesis of experimental amyloid protein A amyloidosis in sore hocks-affected rabbits.2011

    • Author(s)
      Tomoaki Murakami, Yasuo Inoshima, Ken-ichi Watanobe, Yoshiyasu Kobayashi, Takane Matsui, Hisao Kurazono and Naotaka Ishiguro
    • Journal Title

      Amyloid

      Volume: 18 Pages: 112-118

    • Peer Reviewed
  • [Presentation] Potential induction of vaccine-associated amyloid A amyloidosis in white young hens.2012

    • Author(s)
      Tomoaki Murakami, Yasuo Inoshima, Masakazu Inagaki, Eigo Sakamoto, Syouzou Sakamoto, Takuma Yanai and Naotaka Ishiguro
    • Organizer
      XIII International Symposium on Amyloidosis.
    • Place of Presentation
      Groningen, The Netherland
    • Year and Date
      20120506-10
  • [Presentation] 実験的AAアミロイドーシスの伝播2012

    • Author(s)
      村上智亮、猪島康雄、石黒直隆
    • Organizer
      日本獣医学会
    • Place of Presentation
      岩手大学
    • Year and Date
      2012-09-15
  • [Presentation] 育成雛に認められたAAアミロイドーシスの病理学的特徴2012

    • Author(s)
      村上智亮、猪島康雄、酒井洋樹、福士秀人、石黒直隆
    • Organizer
      日本獣医学会
    • Place of Presentation
      岩手大学
    • Year and Date
      2012-09-14
  • [Presentation] ニワトリを用いた実験的AAアミロイド-シスの誘発2012

    • Author(s)
      村上智亮、猪島康雄、柳井徳磨、御領政信、石黒直隆
    • Organizer
      日本獣医学会
    • Place of Presentation
      岩手大学
    • Year and Date
      2012-09-14
  • [Presentation] 牛AAアミロイドーシスにおけるアミロイド沈着パターンの多様性2011

    • Author(s)
      村上智亮、猪島康雄、古林与志安、松井高峯、猪熊 壽、石黒直隆
    • Organizer
      日本獣医学会
    • Place of Presentation
      大阪府立大学
    • Year and Date
      2011-09-19
  • [Presentation] 牛血清アミロイドアイソフォームに対するモノクローナル抗体の作出と牛AA アミロイドの性状解析2011

    • Author(s)
      小崎慧衣、村上智亮、猪島康雄、石黒直隆
    • Organizer
      日本獣医学会
    • Place of Presentation
      大阪府立大学
    • Year and Date
      2011-09-19
  • [Remarks]

    • URL

      http://www1.gifu-u.ac.jp/~naishigu/index.html

URL: 

Published: 2014-08-29  

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