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2013 Fiscal Year Final Research Report

The role of Chlamydia psittaci polymorphic membrane proteins (pmp) in its pathogenesis and in determination of host range.

Research Project

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Project/Area Number 22380166
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionGifu University

Principal Investigator

OHYA Kenji  岐阜大学, 応用生物科学部, 准教授 (50402219)

Co-Investigator(Kenkyū-buntansha) FUKUSHI Hideto  岐阜大学, 応用生物科学部, 教授 (10156763)
Co-Investigator(Renkei-kenkyūsha) OKUDA Hideko  岐阜大学, 大学院連合獣医学研究科, 博士 課程大学院生
HARASAKI Tayo  岐阜大学, 応用生物科学部, 学部学生
Project Period (FY) 2010-04-01 – 2013-03-31
Keywords人獣共通感染症 / 細胞内寄生細菌 / クラミジア / オウム病 / 外膜蛋白質 / 病原性 / 疫学
Research Abstract

Chlamydia psittaci, an obligate intracellular bacterium, is an etiological agent for human psittacosis. In this project, regarding chlamydial pathogenesis and diverse host range, we have focused on the role of the polymorphic membrane protein (pmp) family of C. psittaci. The representative results were as follows. 1) Comparative genomics of the pmp family: Diversity of the pmp family genes were observed in the genomes of intra-chlamydial strains as well as inter-chlamydial species. 2) Expression profile of the Pmp family during growth of C. psittaci: In addition to the constitutively expressed Pmp (e.g.: PmpD), some Pmp (such as PmpG11) were transcribed after the mid-stage of the chlamydial propagation in host cells. 3) Functional analysis of the C. psittaci-specific Pmp: Regarding to the C. psittaci-specific PmpG11, although its contribution to the chlamydial pathogenesis was unknown, the applicability of PmpG11 as a serodiagnostic antigen was revealed and evaluated.

  • Research Products

    (20 results)

All 2013 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 7 results) Presentation (8 results) Book (2 results)

  • [Journal Article] オウム病2013

    • Author(s)
      福士秀人,大屋賢司
    • Journal Title

      小児科

      Volume: 54 Pages: 57-63

    • URL

      http://www.kanehara-shuppan.co.jp/journal/detail.html?kubun=04751&code=047512013010&hakkou_nengetsu=201301

  • [Journal Article] Relatedness between Host Species and Genotype of Beak and Feather Disease Virus Suggesting Possible Interspecies Cross Infection during Bird Trade2013

    • Author(s)
      Ogawa H, Chahota R, Ohya K, Yamaguchi T, Fukushi H
    • Journal Title

      J. Vet. Med. Sci

      Volume: 75 Pages: 503-507

    • DOI

      10.1292/jvms.12-0367

    • Peer Reviewed
  • [Journal Article] Genomic sequence of an infectious bursal disease virus isolate from Zambia: classical attenuated segment B reassortment in nature with existing very virulent segment A2013

    • Author(s)
      Kasanga CJ, Yamaguchi T, Munang'andu HM, Ohya K, Fukushi H
    • Journal Title

      Arch. Virol.

      Volume: 158 Pages: 685-689

    • DOI

      10.1007/s00705-012-1531-4

    • Peer Reviewed
  • [Journal Article] Complete genome sequence of equine herpesvirus type 9 (EHV-9)2012

    • Author(s)
      Fukushi H, Yamaguchi T, Yamada S
    • Journal Title

      J. Virol

      Volume: 86 Pages: 13822

    • DOI

      10.1128/JVI.02607-12

    • Peer Reviewed
  • [Journal Article] Detection of Chlamydophila psittaci by Using SYBR Green Real-Time PCR2011

    • Author(s)
      Okuda H, Ohya K, Shiota Y, Kato H, Fukushi H
    • Journal Title

      J. Vet. Med. Sci

      Volume: 73 Pages: 249-254

    • DOI

      10.1292/jvms.10-0222

    • Peer Reviewed
  • [Journal Article] オウム病クラミジア集団発生事例分離株ゲノム配列決定とその意義2011

    • Author(s)
      大屋賢司,黒田誠,関塚剛史, Garry MEYERS,岸本寿男,安藤秀二,奥田秀子,福士秀人
    • Journal Title

      獣医畜産新報

      Volume: 64 Pages: 804-806

    • URL

      https://buneido-shuppan.com/?gloc_id=03001&bkcd=2011105001

  • [Journal Article] コクシエラ・クラミジア感染症2011

    • Author(s)
      福士秀人
    • Journal Title

      最新医学

      Volume: 66 Pages: 2703-2712

    • URL

      http://www.saishin-igaku.co.jp/backnum/2011/m6612.html

  • [Journal Article] Epidemiology of Chlamydophila caviae-like Chlamydia isolated from urethra and uterine cervix2010

    • Author(s)
      Murao W, Wada K, Matsumoto A, Fujiwara M, Fukushi H, Kishimoto T, Monden K, Kariyama R, Kumon H
    • Journal Title

      Acta Med. Okayama

      Volume: 64 Pages: 1-9

    • URL

      http://escholarship.lib.okayama-u.ac.jp/amo/vol64/iss1

    • Peer Reviewed
  • [Journal Article] A review of DNA viral infections in psittacine birds2010

    • Author(s)
      Katoh H, Ogawa H, Ohya K, Fukushi H
    • Journal Title

      J. Vet. Med. Sci

      Volume: 72 Pages: 1099-1106

    • DOI

      10.1292/jvms.10-0022

    • Peer Reviewed
  • [Journal Article] Using CF0218-ELISA to distinguish Chlamydophila felis-infected cats from vaccinated and uninfected domestic cats2010

    • Author(s)
      Ohya K, Okuda H, Maeda S, Yamaguchi T, Fukushi H
    • Journal Title

      Vet. Microbiol

      Volume: 146 Pages: 366-370

    • DOI

      10.1016/j.vetmic.2010.05.026

    • Peer Reviewed
  • [Presentation] オウム病クラミジアとその感染症における現状と課題2013

    • Author(s)
      福士秀人
    • Organizer
      日本細菌学会
    • Place of Presentation
      千葉
    • Year and Date
      2013-03-18
  • [Presentation] オウム病の理解と制御に向けたとりくみ?ゲノム情報を利用した診断法開発と実態調査2012

    • Author(s)
      大屋賢司
    • Organizer
      戦略的研究基盤形成支援事業「人獣共通感染症の戦略的国際疫学研究の推進と若手研究者の実践的育成」平成24年度シンポジウム
    • Place of Presentation
      藤沢
    • Year and Date
      2012-12-08
  • [Presentation] ガーナ共和国における野鳥のChlamydia属菌保有状況調査2012

    • Author(s)
      奥田秀子
    • Organizer
      日本獣医学会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-15
  • [Presentation] オウム病クラミジアのゲノム解析2012

    • Author(s)
      大屋賢司
    • Organizer
      動物クラミジアを検出するLAMP法の開発
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-15
  • [Presentation] クラミジア肺炎およびオウム病を鑑別するマルチプレックスPCR法の開発2012

    • Author(s)
      原崎多代
    • Organizer
      日本獣医学会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-15
  • [Presentation] Chlamydia psittaci specific genes, which are identified by comparative genomic analysis, can be used for differential diagnosis of chlamydia species2011

    • Author(s)
      Ohya K
    • Organizer
      International Union of Microbiological Societies Congress
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-08
  • [Presentation] Genome sequence of the zoonotic pathogen, Chlamydia psittaci2011

    • Author(s)
      Ohya K
    • Organizer
      Chlamydia basic society meeting
    • Place of Presentation
      California
    • Year and Date
      2011-03-20
  • [Presentation] 鑑別診断法開発と病態解明を目指して2011

    • Author(s)
      大屋賢司
    • Organizer
      日本獣医師会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-02-12
  • [Book] 獣医微生物学「リケッチア」2011

    • Author(s)
      大屋賢司,福士秀人
    • Total Pages
      128-132
    • Publisher
      文永堂(第3版,見上彪監修)
  • [Book] 獣医微生物学「クラミジア」2011

    • Author(s)
      大屋賢司,福士秀人
    • Total Pages
      132-137
    • Publisher
      文永堂(第3版,見上彪監修)

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Published: 2015-07-16  

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