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2012 Fiscal Year Final Research Report

Applied research of phage therapy for bovine mastitis

Research Project

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Project/Area Number 22380174
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionRakuno Gakuen University

Principal Investigator

IWANO Hidetomo  酪農学園大学, 獣医学群, 准教授 (60382488)

Co-Investigator(Kenkyū-buntansha) HIGUCHI Hidetosi  酪農学園大学, 獣医学群, 准教授 (00305905)
INOUE Hiroki  酪農学園大学, 食品環境学群, 准教授 (90305904)
Project Period (FY) 2010 – 2012
Keywordsファージセラピー / 黄色ブドウ球菌 / 牛乳房炎 / MRSA
Research Abstract

In this work, we isolated novel two bacteriophages for Staphylococcus aureus (SA) with wide host ranges from sewage, and examined carefully their potential as therapeutic agents using experimental murine mastitis. All 99 strains of SA isolated from distinct ruminants with mastitis were completely lysed by SA bacteriophage. SA bacteriophage inhibited the SA growth in the mammary gland of experimental murine mastitis.

  • Research Products

    (20 results)

All 2012 2011 2010

All Journal Article (9 results) Presentation (8 results) Book (3 results)

  • [Journal Article] Effects of vitamin E supplementation on cellular a-tocopherol concentrations of neutrophils in Holstein calves2012

    • Author(s)
      Higuchi, H., Ito, E., Iwano, H., Oikawa, S. and Nagahata, H
    • Journal Title

      Can. J. Vet. Res

  • [Journal Article] Analysis of trace and major elements in bronchoalveolar lavage fluid of Mycoplasma bronchopneumonia in calves2012

    • Author(s)
      Suzuki K, Higuchi H, Iwano H, Lakritz J, Sera K, Koiwa M, Taguchi K
    • Journal Title

      Biol. Trace. Elem. Res.Feb

      Volume: 145(2):166-71

  • [Journal Article] L-Type Amino Acid Transporter 1 (LAT1) Expression in Canine Mammary Gland Tumors2012

    • Author(s)
      Fukumoto S, Hanazono K, Komatsu T, Iwano H, Kadosawa T, Uchide T
    • Journal Title

      J. Vet. Med. Sci. Nov

      Volume: 22

  • [Journal Article] Pathological classification of canine mammary tumor based on quantifying mRNA levels of hormonal receptors, SATB1, and snail in tissue and fine needle biopsy samples2012

    • Author(s)
      Komatsu T, Iwano H, Ebisawa M, Watabe A, Endo Y, Hirayama K, Taniyama H, Kadosawa T
    • Journal Title

      J.Vet. Med. Sci

      Volume: 74(6):719-26

  • [Journal Article] A simplified PCR assay for fast and easy mycoplasma mastitis screening in dairy cattle2011

    • Author(s)
      Higuchi, H., Iwano, H., Kawai, K., Ohta, T., Obayashi, T., Hirose, K., Itoh, N., Yokota, T., Tamura, Y. and Nagahata, H
    • Journal Title

      J. Vet. Sci

      Volume: 12: 191-193

  • [Journal Article] Prevalence of Mycoplasma species in bulk tank milk in Japan2011

    • Author(s)
      Higuchi, H., Iwano, H., Gondaira, S., Kawai, K., Nagahata, H
    • Journal Title

      Vet. Rec

      Volume: 169:442

  • [Journal Article] Analysis of trace and major elements in bronchoalveolar lavage fluid of mycoplasma bronchopneumonia in calves2011

    • Author(s)
      Suzuki, K., Higuchi, H., Iwano, H., Lakritz, J., Sera, K., Koiwa, M., Taguchi, K
    • Journal Title

      Biol. Trace. Elem. Res

      Volume: 145:166-171

  • [Journal Article] Placental Transfer of Conjugated Bisphenol A and Subsequent Reactivation in the Rat fetus2010

    • Author(s)
      Nishikawa M., Iwano H., Yanagisawa R., Koike N., Inoue H., and Yokota H
    • Journal Title

      Environ. Health Perspect

      Volume: 118 Pages: 1196-1203

  • [Journal Article] Histone H1 null vertebrate cells exhibit altered nucleosome architecture2010

    • Author(s)
      Hashimoto H, Takami Y, Sonoda E, Iwasaki T, Iwano H, Tachibana M, Takeda S, Nakayama T, Kimura H, Shinkai Y
    • Journal Title

      Nucleic Acids Res

      Volume: 383533-45

  • [Presentation] Characterization of novel Staphylococcus aureus bacteriophages with wide host ranges and their potential as therapeutic agents for bovine mastitis.2012

    • Author(s)
      Iwano, H., Higuchi, H., Inoue, H., Kobayashi, H., Nagahata, H., Yokota, H., Tanji, Y., Tamura, Y
    • Organizer
      World buiatrics congress 2012
    • Place of Presentation
      Lisbon
    • Year and Date
      20120600
  • [Presentation] 乳房炎由来ブドウ球菌に対するバクテリオファージの有効性と体内動態2012

    • Author(s)
      小林弘典、 岩野英知、 樋口豪紀、 井上博紀、萩原克郎、丹治保典、永幡肇、田村豊、横田博
    • Organizer
      第153回日本獣医学会学術集会
    • Year and Date
      20120000
  • [Presentation] Mycoplasma bovisがウシ単核球サイトカイン mRNA の発現量に及ぼす影響2012

    • Author(s)
      権平智、樋口豪紀、岩野英知、永幡肇
    • Organizer
      第153回日本獣医学会学術集会
    • Year and Date
      20120000
  • [Presentation] マイコプラズマ性乳房炎の摘発を目的としたバルクスクリーニングの実施とその評価2011

    • Author(s)
      樋口豪紀、岩野英知、河合一洋、永幡肇
    • Organizer
      平成 23 年度北海道獣医師大会
    • Year and Date
      20110000
  • [Presentation] ウシ乳房炎由来ブドウ球菌に対するバクテリオファージの有効性と体内動態2011

    • Author(s)
      小林弘典、岩野英知、樋口豪紀、井上博紀、丹治保典、永幡肇、横田博、田村豊
    • Organizer
      第152回日本獣医学会学術集会
    • Year and Date
      20110000
  • [Presentation] 黄色ブドウ球菌の乳腺感染モデルマウスに対するファージセラピーの検討2010

    • Author(s)
      岩野英知、樋口豪紀、井上博紀、井上裕介、高砂拓志、萩原克郎、丹治保典、永幡肇、横田博
    • Organizer
      第150回日本獣医学会学術集会
    • Year and Date
      20100000
  • [Presentation] 北海道におけるウシ乳房炎由来マイコプラズマ種の浸潤調査2010

    • Author(s)
      伊藤暢彦、樋口豪紀、岩野英知、河合一洋、大林哲、永幡肇
    • Organizer
      平成 22 年度北海道獣医師大会
    • Year and Date
      20100000
  • [Presentation] 黄色ブドウ球菌に対する特異的なファージを用いたウシ乳房炎治療応用への可能性2010

    • Author(s)
      岩野英知、樋口豪紀、 井上博紀、萩原克郎、横田博、永幡肇、丹治保典、田村豊
    • Organizer
      乳房炎研究会
    • Year and Date
      20100000
  • [Book] 「バクテリオファージ」による乳房炎治療への応用酪農ジャーナル2012

    • Author(s)
      岩野英知
    • Total Pages
      32-34
    • Publisher
      酪農学園大学エクステンションセンター
  • [Book] 細菌の生き残り戦略~最も繁栄している生物の仕組み~2012

    • Author(s)
      岩野英知
    • Total Pages
      11-13
    • Publisher
      The Japanese Society for Animal Vaccine and Biomedical Research NEWS letter
  • [Book] 犬と猫の早期疾病診断学2011

    • Author(s)
      岩野英知, 予防動物医学研究会編(新井敏郎ほか)
    • Total Pages
      90-93
    • Publisher
      チクサン出版社(緑書房)

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Published: 2014-08-29  

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