2012 Fiscal Year Final Research Report
Structural insight into the signal transduction mechanism of TRAF6related proteins
Project/Area Number |
22390008
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Physical pharmacy
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Research Institution | Kumamoto University |
Principal Investigator |
YAMAGATA Yuriko 熊本大学, 大学院・生命科学研究部, 教授 (40183678)
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Project Period (FY) |
2010 – 2012
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Keywords | タンパク質 / シグナル伝達 / 構造生物学 |
Research Abstract |
Tumor necrosis factor (TNF) is a well-known inflammatory cytokine that is implicatedin several autoimmune diseases such as rheumatoid arthritis. Here we show the firstcrystal structure of the TNF-TNFR2 complex. Structural differences between TNFR1 andTNFR2 are analyzed and discussed. This data will be key to the future development oflow-toxic TNFR1 selective therapies. In addition, we also reveal the formation of a TNFR2supra-complex on the cell surface. Aggregation of these receptors may contribute to thecurrently unidentified mechanism of TNFR superfamily signal initiation.Tumor necrosis factor receptor-associated factor 6 (TRAF6) transduces signals frommembers of the Toll/interleukin-1 (IL-1) receptor and TNFR families. Here we show thatthe first crystal structure of the TRAF6 binding protein. The TRAF6 binding protein formsa dimer.
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[Journal Article] Structural Insights into Differences inDrug-binding Selectivity between Two Forms ofHuman1-Acid Glycoprotein Genetic Variants,the A and F1*S Forms2011
Author(s)
K Nishi, T Ono, TNakamura, N Fukunaga, M Izumi, H Watanabe,A Suenaga, T Maruyama, Y Yamagata, S Curryand M Otagiri, J
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Journal Title
Biol. Chem
Volume: 286
Pages: 14427-14434
Peer Reviewed
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[Journal Article] The crystal structure of the green teapolyphenol(-)-epigallocatechingallate (EGCG)-transthyretin complex reveals a novel bindingsite distinct from the thyroxine binding site2010
Author(s)
MMiyata, T Sato, M Kugimiya, M Sho, TNakamura, S Ikemizu, M Chirifu, M Mizuguchi, YNabeshima, Y Suwa, H Morioka, T Arimori, M ASuico, T Shuto, Y Sako, M Momohara, T Koga, SMorino-Koga, Y Yamagata and H Kai
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Journal Title
Biochemistry
Volume: 49
Pages: 6104-6114
Peer Reviewed
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[Presentation] Crystal Structure of lnterleukin-232011
Author(s)
TakumiShirouzono, Mami Chirifu, Chiharu Nakamura,Teruya Nakamura, Yuriko Yamagata, ShinjiIkemizu
Organizer
17thInternational Conference ofBiophysics
Place of Presentation
Beijing, China
Year and Date
2011-11-03
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[Remarks] 報道関係TNF と TNFR2 複合体の X 線結晶構造解析の成果が、平成22年12月27日(月)に日刊薬業の10 面と日経産業新聞の10面に掲載された。
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[Remarks] アウトリーチ活動平成23年度熊本大学女子中高校生の理系進路選択支援事業 平成23年10月22日(熊本大学医学部保健学科)
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[Remarks] 「立体構造の美しいタンパク質に魅せられて」約20名の女子中高校生にタンパク質の立体構造決定に関する話をした。参加者の9割が、理系科目の勉強は将来の自分にとって必要と思うや理系のイメージ好感度がアップした、8割が科学技術に関係する職業に就きたいと思う等のアンケートの結果を得た。