2012 Fiscal Year Final Research Report
Molecular mechanisms linking energy metabolism and thermoregulation
| Project/Area Number |
22390014
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
UMEDA Masato 京都大学, 大学院・工学研究科, 教授 (10185069)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Utako 京都大学, 大学院・工学研究科, 助教 (90362392)
JUNI Naoto 京都大学, 大学院・工学研究科, 研究員 (90572199)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 体温調節 / エネルギー代謝 / 脂質代謝 / メタボリックシンドローム / ショウジョウバエ |
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| Research Abstract |
For ectothermic animals, behavior plays a major role in thermoregulation; a wide variety of animals sense the environmental temperature and move towards to thermally comfortable zone. Although most ectothermic animals do not use metabolically produced heat to regulate body temperature, we found that thermoregulatory behavior of Drosophila is highly dependent on the level of energy metabolism; the increase in mitochondrial oxidative phosphorylation induced preference for the low temperature (Science 323:1740-1743, 2009), while the suppression of energy metabolism by inhibiting insulin signaling caused a warm-seeking thermoregulatory behavior. During the course of identifying molecules involved in the control of energy homeostasis, we found that delta-9 fatty acid desaturase (desat1) expressed in the fat body, a tissue equivalent to mammalian liver and adipose tissue, played a pivotal role in the control of energy metabolism as well as thermoregulatory behavior. Defective expression of desat1 suppressed mitochondrial oxidative phosphorylation, causing a significant decrease in body size and warm-seeking phenotype. In contrast, induced expression of delta-12 fatty acid desaturase (Caenorhabditis elegansFat-2) that produces linoleic acid caused the increase in body size and the low-temperature preference. These observations suggest that the changes in lipid desaturation coordinately regulate mitochondrial energy metabolism and thermoregulatory behavior.
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[Journal Article] The role of nadrin, a Rho GTPase-activating protein, in the morphological differentiation of astrocytes2013
Author(s)
Kobayashi, Y., Harada, A., Furuta, B., Asou, H., Kato, U., Umeda, M.:
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Journal Title
J Biochem
Volume: 153
Pages: 389-398
DOI
Peer Reviewed
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[Journal Article] Upregulated function of mitochondria-associated ER membranes in Alzheimer disease2012
Author(s)
Area-Gomez, E., Castillo, M., Tambini, M., Groof1a, A., Madra, M., Ikenouchi, J., Umeda, M., Bird, T., Sturley, S., Schon, E
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Journal Title
EMBOJ
Volume: 31
Pages: 4106-23
DOI
Peer Reviewed
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[Journal Article] Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis.2012
Author(s)
Lee, S., Uchida1, Y., Emoto, K., Umeda, M., Kuge, O., Taguchi, T., Arai, H
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Journal Title
Genes to Cells
Volume: 17
Pages: 728-36
DOI
Peer Reviewed
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[Journal Article] Lipid polarity is maintained in absence of tight junctions2012
Author(s)
Ikenouchi, J., Suzuki, M., Umeda, K., Ikeda, K., Taguchi, R., Kobayashi, T., Sato SB, Kobayashi. T, Stolz DB., Umeda, M
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Journal Title
J Biol Chem
Volume: 287(12)
Pages: 9525-33
DOI
Peer Reviewed
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[Journal Article] TP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50-independent manner2011
Author(s)
Takatsu, H., Baba, K., Shima, T., Umino, H., Kato, U., Umeda, M., Nakayama, K., Shin, H.W
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Journal Title
J. Biol. Chem
Volume: 286(44)
Pages: 38159-67
DOI
Peer Reviewed
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[Journal Article] Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes2011
Author(s)
Nakayama, M., Sato, H., Okuda, T., Fujisawa, N., Kono, N., Arai, H., Suzuki, E., Umeda, M., Ishikawa, H.O., Matsuno, K
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Journal Title
PLoS One
Volume: 6
Pages: e22984
DOI
Peer Reviewed
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