2012 Fiscal Year Final Research Report
Drug development on protein misfolding diseases
| Project/Area Number |
22390015
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
KAI Hirofumi 熊本大学, 大学院・生命科学研究部, 教授 (30194658)
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| Co-Investigator(Kenkyū-buntansha) |
SHUTO Tsuyoshi 熊本大学, 大学院・生命科学研究部, 准教授 (80333524)
MARY ANN Suico 熊本大学, 大学院・生命科学研究部, 助教 (20363525)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 薬理学 / タンパク質 / 遺伝病 / cystic fibrosis / FAP / CFTR / transthyretin |
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| Research Abstract |
Drug development for cystic fibrosis (CF) and familial amyloidpolyneuropathy (FAP) is still in progress. We established the CF-like model mouse stablyproducing sputum to evaluate various kinds of medicine, and we found a novel mechanismfor the endoplasmic reticulum-associated degradation of transthyretin variants inmammalian cells
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[Journal Article] STT3B-dependent posttranslationalN-glycosylation as a novel surveillancesystem for secretory protein2012
Author(s)
Sato T, Sako Y, Sho M, Momohara M, SuicoMA, Shuto T, Nishitoh H, Okiyoneda T,Kokame K, Kaneko M, Taura M, Miyata M,Chosa K, Koga T, Koga SM, Wada I, Kai H
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Journal Title
Mol. Cell
Volume: 47
Pages: 99-110
Peer Reviewed
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[Journal Article] Rb/E2F1 Regulatesthe Innate Immune Receptor Toll-LikeReceptor 3 in Epithelial Cells2012
Author(s)
Taura M, Suico MA, Koyama K, Komatsu K,Miyakita R, Matsumoto C, Kudo E, Kariya R,Goto H, Kitajima S, Takahashi C, Shuto T,Nakao M, Okada S, Kai H
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Journal Title
Mol. Cell.Biol
Volume: 32
Pages: 1581-90
Peer Reviewed
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[Journal Article] CFTR-deficiency renders mice highlysusceptible to cutaneous symptoms duringmite infestation2011
Author(s)
Hashimoto Y, Shuto T, Mizunoe S, TomitaA, Koga T, Sato T, Takeya M, Suico MA,Niibori A, Sugahara T, Shimasaki S,Sugiyama T, Scholte B, Kai H
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Journal Title
Lab Invest
Volume: 91(4)
Pages: 509-18
Peer Reviewed
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[Journal Article] Role of theglutamic acid 54 residue in transthyretin stability and thyroxine binding2010
Author(s)
Miyata M, Sato T, Mizuguchi M, NakamuraT, Ikemizu S, Nabeshima Y, Susuki S, SuwaY, Morioka H, Ando Y, Suico MA, Shuto T,Koga T, Yamagata Y, and Kai H
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Journal Title
Biochemistry
Volume: 49
Pages: 114-23
Peer Reviewed
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[Journal Article] Crystal structure of green teapolyphenol(-)-epigallocatechin gallate(EGCG)-transthyretin complex revealsnovel binding site distinct fromthyroxine binding site2010
Author(s)
Miyata M, Sato T, Kugimiya M, Sho M,Nakamura T, Ikemizu S, Chirifu M,Mizuguchi M, Nabeshima Y, Suwa Y, MoriokaH, Arimori T, Suico MA, Shuto T, Sako Y,Momohara M, Koga T, Morino-Koga S, YamagataY, Kai H
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Journal Title
Biochemistry
Volume: 49
Pages: 6104-14
Peer Reviewed
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[Journal Article] Curcumindecreases toll-like receptor-2 geneexpression and function in human monocytesand neutrophils2010
Author(s)
Shuto T, Ono T, Ohira Y, Shimasaki S,Mizunoe S, Watanabe K, Suico MA, Koga T,Sato T, Morino S, Sato K, Kai H
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Journal Title
Biochem Biophys ResCommun
Volume: 398(4)
Pages: 647-52
Peer Reviewed
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