2013 Fiscal Year Final Research Report
Heparanase and extracellular matrices regulate cellular trafficking and function of inflammatory immune cells.
| Project/Area Number |
22390023
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HIGASHI Nobuaki 東京大学, 薬学研究科(研究院), 准教授 (40302616)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 微生物・感染症学 / 細胞外マトリックス / ヘパラナーゼ / ヘパラン硫酸 / 炎症 / マスト細胞 / ヘパリン / コラーゲン |
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| Research Abstract |
Regulatory process of local inflammation is studied via degradation or downsizing of extracellular matrices by their degrading enzymes, especially on heparan sulfate and heparanase. Heparanase is involved in extravasation of neutrophils and monocytes in a local inflammation in mouse dorsal air pouches as well as in in vitro transmigration assay. Enzyme activity is likely to be regulated by differential localization of the enzyme molecules. Cleavage of granular heparin in the secretory granules of mast cells accelerates the release of granular materials from extracellular matrices. From the data, roles of heparanase are convincingly shown as a critical enzyme in induction and duration of inflammation.
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[Journal Article] Loss of UDP-GalNAc : polypeptide N-acetylgalactosaminyltransferase 3 and reduced O-glycosylation in colon carcinoma cells selected for hepatic metastasis2010
Author(s)
Kato K, Takeuchi H, Kanoh A, Miyahara N, Nemoto-Sasaki Y, Morimoto-Tomita M, Matsubara A, Ohashi Y, Waki M, Usami K, Mandel U, Clausen H, Higashi N, Irimura T
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Journal Title
Glycoconj J
Volume: 27(2)(IF:1.882)
Pages: 437-445
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[Journal Article] Potentiation of proliferation of some but not all human colon carcinoma cell lines by immobilized hepatic asialoglycoprotein receptor 12009
Author(s)
Fang J, Izawa R, Gomez-Santos L, Ueno S, Sawaguchi T, Usami K, Nodera Y, Takeuchi H, Ohashi Y, Higashi N, Irimura T
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Journal Title
Oncol. Res
Volume: 17(10)(IF:1.634)
Pages: 437-445
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[Journal Article] Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices
Author(s)
Higashi N, Waki M, Sue M, Kogane Y, Shida H, Tsunekawa N, Hasan A, Sato T, Kitahara A, Kasaoka K, Hayakawa Y, Nakajima M, Irimura T
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Journal Title
Biochem J
Volume: (in press)(IF: 4.654)
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[Presentation] Roles of heparanase expression in local and systemic inflammation2012
Author(s)
Hiroaki Shida, Mayumi Sue, Noriko Komatsu, Michihiko Waki, Yoshio Nishimura, Motowo Nakajima, Nobuaki Higashi and Tatsuro Irimura
Organizer
International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences
Place of Presentation
Ito Memorial Hall, The University of Tokyo, Tokyo
Year and Date
20121130-1201
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[Presentation] Heparanase regulates immune cell functions2011
Author(s)
Higashi N, Sasaki N, Komatsu N, Taka T, Waki M, Sue M, Kogane Y, Kolaczkowska E, Nishimura Y, Nakajima M, Irimura T
Organizer
Second Polish Congress of Biochemistry and Cell Biology
Place of Presentation
Krakow
Year and Date
20110905-09
Invited
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