2012 Fiscal Year Final Research Report
Multipotential stem cell-like nature of bone marrow-derived macrophages accumulated in lesion core of acute and severe brain injuries.
| Project/Area Number |
22390037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Ehime University |
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Principal Investigator |
TANAKA Junya 愛媛大学, プロテオ医学研究センター, 教授 (70217040)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Hajime 愛媛大学, 大学院・医学系研究科, 准教授 (00284414)
TAKAHASHI Hisaaki 愛媛大学, 医学部附属病院, 講師 (20363228)
SUGIMOTO Kana 愛媛大学, 大学院・医学系研究科, 助教 (00581034)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNISHI Takanori 愛媛大学, 大学院・医学系研究科, 教授 (70233210)
KUMON Yoshiaki 愛媛大学, 大学院・医学系研究科, 准教授 (80127894)
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| Project Period (FY) |
2010 – 2012
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| Keywords | マクロファージ / マイクログリア / 骨髄 / 分化多能性 / 神経細胞保護作用 / 単球 |
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| Research Abstract |
Many bone marrow-derived macrophages were found to accumulate in lesion cores of stroke and traumatic brain injuries. Because most of the cells expressed a multipotent cell marker in the brain, NG2 chondroitin sulfate proteoglycan as well as a macrophage marker Iba1, they were termed BINCs (Brain Iba1^+/NG2^+Cells). BINCs exerted neuroprotective actions and promoted regeneration and restoration of injured tissue by releasing neuroprotective growth factors and scavenging degenerated cellsand tissues. We found that injection of a cytokine mixture (IL3 and GM-CSF) markedly ameliorated traumatic brain injury and Parkinson’s disease.
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[Journal Article] Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions2013
Author(s)
Nari Tei, Junya Tanaka, Kana Sugimoto, Tasuku Nishihara, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Shirabe Matsumoto, Shiro Ohue, Hideaki Watanabe, Yoshiaki Kumon, Takanori Ohnishi
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Journal Title
J Neurosci Res
Volume: 91
Pages: 681-693
Peer Reviewed
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[Journal Article] Oct-3/4 promotes migration and invasion of glioblastoma cells.2012
Author(s)
Kobayashi K, Takahashi H, Inoue A, Harada H, Toshimori S, Kobayashi Y, Goto K, Sugimoto K, Yano H, Ohnishi T, Tanaka J.
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Journal Title
J Cell Biochem
Volume: 113
Pages: 508-517
Peer Reviewed
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[Journal Article] Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages.2011
Author(s)
NakataT, Kawachi K, Nagashima M, Yasugi T, Izutani H, Ryugo M, Okamura T, Shikata F, Imagawa H, Yano H, Takahashi H, Tanaka J.
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Journal Title
Brain Res
Volume: 1420
Pages: 114-124
Peer Reviewed
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[Journal Article] Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity.2010
Author(s)
Inoue, A., Takahashi, H., Harada, H., Kohno, S., Ohue, S., Kobayashi, K., Yano, H., Tanaka, J., Ohnishi, T.
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Journal Title
Int J Oncol
Volume: 37
Pages: 1121-1131
Peer Reviewed
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